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Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells

Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells
Posted by Nicole

Since ZIKV was first detected at Uganda in 1947 and, severe outbreaks have globally occurred within the Yap Island, the French Polynesia and Brazil. Although the variety of an infection and unfold of ZIKV have sharply rise, the pathogenesis or replication mechanisms ZIKV haven’t been properly studied. Zika virus (ZIKV) is lately highlighted Flavivirus, a mosquito born rising virus inflicting microcephaly and the Guillain-Barre syndrome in fetuses and adults, respectively. ZIKV polyprotein consists of three structural proteins named C, prM and E and 7 nonstructural proteins named NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 in 11-kb single-stranded constructive sense RNA genome. The perform of particular person ZIKV genes on the host innate immune responses have been barely studied.

On this research, we investigated the modulations of the NF-κB promoter exercise associated by the MDA5/RIG-I signaling pathway. Within the outcomes, two nonstructural proteins, NS2A and NS4A, dramatically suppressed the NF-κB promoter exercise by inhibiting signaling elements on MDA5/RIG-I signaling pathway associated to activation of NF-κB. Apparently, NS2A suppressed all parts of MDA5/RIG-I signaling pathway, however NS4A inhibited most signaling molecules, besides IKKε and IRF3-5D. As well as, each NS2A and NS4A down-regulated MDA5 associated NF-κB promoter exercise in dose-dependent method. Taken collectively, our outcomes introduced that NS2A and NS4A critically antagonize MDA5/RIG-I-mediated NF-κB manufacturing and people proteins could appear to be managed in several mechanisms. This research might assist perceive the mechanisms how ZIKV controls innate immune responses and could also be supplied for improvement of ZIKV-specific medicines.

 

 

Cytochrome P450 1A2 overcomes nuclear issue kappa B-mediated sorafenib resistance in hepatocellular carcinoma

Sorafenib resistance has grow to be the primary impediment within the efficient therapy of superior hepatocellular carcinoma (HCC) sufferers. Activation of nuclear issue kappa B (NF-κB) is a newly recognized mechanism that contributes to desensitized sorafenib. Cytochrome P450 1A2 (CYP1A2) capabilities as a tumor suppressor in HCC and its expression is negatively related to NF-κB within the liver. This research aimed to check whether or not CYP1A2 might overcome sorafenib resistance. To analyze whether or not CYP1A2 and NF-κB p65 performed roles in sorafenib desensitization, we established sorafenib-resistant (SR) HCC cells.
SR cells decreased the expression of CYP1A2 together with the upregulation of NF-κB p65. CYP1A2 overexpression attenuated SR cell proliferation, elevated sorafenib sensitivity, and inhibited the NF-κB pathway, whereas CYP1A2 silence confirmed reverse results. Sorafenib, together with omeprazole, a CYP1A2 inducer, considerably hindered the expansion and invasion of SR cells in vitro in addition to decreased the tumor development in vivo. The mixture therapy markedly elevated CYP1A2 expression and inhibited the sorafenib-induced NF-κB signaling. As well as, the overexpression of NF-κB p65 stimulated the SR cell development and desensitized sorafenib in SR cells, the place CYP1A2 overexpression reversed the phenomenon. Lastly, nearly all of HCC tissue samples displayed decreased CYP1A2 however elevated NF-κB p65 protein expression. Collectively, CYP1A2 can sensitize SR cells to sorafenib by way of inhibiting NF-κB p65 axis. Omeprazole together with sorafenib exerts a synergistic impact in assuaging acquired sorafenib resistance.
 Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells
Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells

Nuclear issue erythroid 2-related issue 2 (Nrf2) as a possible therapeutic goal for vitiligo

Vitiligo is an autoimmune illness of the pores and skin which causes lack of melanocytes from the dermis. Not too long ago, it’s demonstrated that oxidative stress (OS) performs a big function within the immuno-pathogenesis of vitiligo. A serious mechanism within the mobile protection in opposition to OS is activation of the nuclear issue erythroid2-related issue (Nrf2)-Kelch-like ECH-associated protein 1(Keap1)-antioxidant responsive aspect (ARE) signaling pathway. Not too long ago it has been proven that vitiligo melanocytes have impaired Nrf2-ARE signaling. Plenty of medicine together with these often called Nrf2 activators and people identified to own results to activate Nrf2, have been utilized in treating vitiligo with sure therapeutic results.
Additionally, research have proven that quite a lot of compounds can shield melanocytes in opposition to OS by way of activating Nrf2. These compounds could also be thought of as candidates for creating new medicine for vitiligo sooner or later. Nrf2 might be thought of as a possible therapeutic goal for vitiligo. This text ready a simvastatin-NLCs for the therapy of arteriosclerotic occlusive illness of decrease limbs. Taking the scale distribution, polydispersity coefficient, encapsulation effectivity and drug loading of simvastatin-NLCs as analysis indicators, numerous prescription elements of simvastatin- NLCs had been investigated. The in vitro launch conduct and stability of simvastatin-NLCs had been additionally investigated. A hyperlipidemia rat mannequin was established utilizing high-fat diets.

Goat anti Human kappa chain

41R-1041 1 mg
EUR 309
Description: Goat anti Human kappa chain secondary antibody

Goat anti Human kappa chain

41R-1042 1 mg
EUR 318
Description: Goat anti Human kappa chain secondary antibody

Goat anti Human Kappa Chain

MBS539844-1mg 1mg
EUR 515

Goat anti Human Kappa Chain

MBS539844-5x1mg 5x1mg
EUR 2155

Goat Anti Human Kappa Light Chain Polyclonal Antibody,HRP

CPBT-65573GH 1 ml
EUR 696

Goat Anti Human Kappa Light Chain Polyclonal Antibody,FITC

CPBT-65572GH 1 mg
EUR 696

Goat anti Human Kappa Chain (HRP)

43C-CB9126 1 mg
EUR 385
Description: Goat anti Human Kappa Chain secondary antibody (HRP)

Goat anti Human kappa chain (HRP)

43R-1260 500 ug
EUR 352
Description: Goat anti Human kappa chain secondary antibody (HRP)

Goat anti Human kappa chain (HRP)

43R-1266 500 ug
EUR 418
Description: Goat anti Human kappa chain secondary antibody (HRP)

Goat anti Human Kappa Chain (HRP)

MBS536351-1mg 1mg
EUR 720

Goat anti Human Kappa Chain (HRP)

MBS536351-5x1mg 5x1mg
EUR 3090

Goat anti Human Kappa Chain (FITC)

43C-CB9122 1 mg
EUR 347
Description: Goat anti Human Kappa Chain secondary antibody (FITC)

Goat anti Human kappa chain (FITC)

43R-1259 500 ug
EUR 343
Description: Goat anti Human kappa chain secondary antibody (FITC)

Goat anti Human kappa chain (FITC)

43R-1265 500 ug
EUR 398
Description: Goat anti Human kappa chain secondary antibody (FITC)

Goat anti Human Kappa Chain (FITC)

MBS536347-1mg 1mg
EUR 655

Goat anti Human Kappa Chain (FITC)

MBS536347-5x1mg 5x1mg
EUR 2805

Goat anti Human Kappa light chain

20-S2301G000-S4 10 ml
EUR 100
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2301G000-V0 10 ml
EUR 75
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2501G000-V0 10 ml
EUR 110
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2503GND1-D0 5 ml
EUR 150
Description: Goat anti Human Kappa light chain antibody

GOAT ANTI HUMAN KAPPA LIGHT CHAIN

MBS222991-1mg 1mg
EUR 320

GOAT ANTI HUMAN KAPPA LIGHT CHAIN

MBS222991-5x1mg 5x1mg
EUR 1255

GOAT ANTI HUMAN KAPPA LIGHT CHAIN

MBS224019-1mL 1mL
EUR 320

GOAT ANTI HUMAN KAPPA LIGHT CHAIN

MBS224019-5x1mL 5x1mL
EUR 1255

Goat anti Human Kappa Chain (biotin)

43C-CB9125 1 mg
EUR 347
Description: Goat anti Human Kappa Chain secondary antibody (biotin)

Goat anti Human kappa chain (biotin)

43R-1258 500 ug
EUR 367
Description: Goat anti Human kappa chain secondary antibody (biotin)

Goat anti Human kappa chain (biotin)

43R-1264 500 ug
EUR 440
Description: Goat anti Human kappa chain secondary antibody (biotin)

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:RPE

MBS222149-05mg 0.5mg
EUR 700

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:RPE

MBS222149-5x05mg 5x0.5mg
EUR 2975

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:HRP

MBS222993-1mL 1mL
EUR 370

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:HRP

MBS222993-5x1mL 5x1mL
EUR 1500

Goat anti Human Kappa Chain (biotin)

MBS536350-1mg 1mg
EUR 655

Goat anti Human Kappa Chain (biotin)

MBS536350-5x1mg 5x1mg
EUR 2805

Goat anti-Human Kappa Light Chain Antibody

nAP-20103 100ug
EUR 255

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:FITC

MBS222992-1mg 1mg
EUR 345

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:FITC

MBS222992-5x1mg 5x1mg
EUR 1375

Goat anti Human Kappa Chain (rhodamine)

43C-CB9123 1 mg
EUR 347
Description: Goat anti Human Kappa Chain secondary antibody (Rhodamine)

Goat anti Human kappa chain (rhodamine)

43R-1261 500 ug
EUR 343
Description: Goat anti Human kappa chain secondary antibody (rhodamine)

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:Biotin

MBS220086-1mg 1mg
EUR 370

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:Biotin

MBS220086-5x1mg 5x1mg
EUR 1500

Goat anti Human Kappa Chain (rhodamine)

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Goat anti Human Kappa Chain (rhodamine)

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Goat Anti-Mouse Kappa antibody (AU)

STJ99353-100l 100 µl
EUR 214.8
Description: AU conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (AU)

STJ99353-1mL 1 mL
EUR 1198.8
Description: AU conjugated Goat polyclonal to Mouse Kappa

Goat Anti Human Kappa Chain-Rhodamine

GWB-DL0251 1 mg Ask for price

Goat Anti-Mouse Kappa antibody (HRP)

STJ99503-100l 100 µl
EUR 214.8
Description: HRP conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (HRP)

STJ99503-1mL 1 mL
EUR 1198.8
Description: HRP conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (FITC)

STJ99453-100l 100 µl
EUR 214.8
Description: FITC conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (FITC)

STJ99453-1mL 1 mL
EUR 1198.8
Description: FITC conjugated Goat polyclonal to Mouse Kappa

Goat anti Human Kappa Chain (Fab'2)

41C-CJ0129 1 mg
EUR 338
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2)

Goat anti Human Kappa Chain (Fab'2)

MBS536027-1mg 1mg
EUR 665

Goat anti Human Kappa Chain (Fab'2)

MBS536027-5x1mg 5x1mg
EUR 2850

Goat Anti-Mouse Kappa antibody (Biotin)

STJ99403-100l 100 µl
EUR 214.8
Description: Biotin conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (Biotin)

STJ99403-1mL 1 mL
EUR 1198.8
Description: Biotin conjugated Goat polyclonal to Mouse Kappa

Goat anti Human Kappa Chain (Alk Phos)

43C-CB9127 1 mg
EUR 403
Description: Goat anti Human Kappa Chain secondary antibody (Alk Phos)

Goat anti Human kappa chain (Alk Phos)

43R-1257 500 ug
EUR 398
Description: Goat anti Human kappa chain secondary antibody (Alk Phos)

Goat anti Human Kappa Chain (Alk Phos)

MBS536352-1mg 1mg
EUR 745

Goat anti Human Kappa Chain (Alk Phos)

MBS536352-5x1mg 5x1mg
EUR 3210

Goat anti Human Kappa Chain (Texas Red)

43C-CB9124 1 mg
EUR 347
Description: Goat anti Human Kappa Chain secondary antibody

Goat anti Human Kappa Chain (Texas Red)

MBS536349-1mg 1mg
EUR 655

Goat anti Human Kappa Chain (Texas Red)

MBS536349-5x1mg 5x1mg
EUR 2805

Goat F(Ab')2 Anti Human Kappa Light Chain Polyclonal Antibody,RPE

CPBT-65578GA 0.5 ml
EUR 696

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:Alk. Phos.

MBS220008-1mL 1mL
EUR 430

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:Alk. Phos.

MBS220008-5x1mL 5x1mL
EUR 1770

Goat anti Human Kappa + Lambda light chain

20-S1701G000-V0 10 ml
EUR 100
Description: Goat anti Human kappa + lambda light chain secondary antibody

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:Texas Red

MBS222632-1mg 1mg
EUR 345

GOAT ANTI HUMAN KAPPA LIGHT CHAIN:Texas Red

MBS222632-5x1mg 5x1mg
EUR 1375

Goat F(Ab')2 Anti Human Kappa Light Chain Polyclonal Antibody,Biotin

CPBT-65575GA 0.5 mg
EUR 696

Goat anti Human Kappa Chain (Fab'2) (HRP)

43C-CJ0132 1 mg
EUR 506
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2) (HRP)

Goat anti Human Kappa Chain (Fab'2) (HRP)

MBS536358-1mg 1mg
EUR 1015

Goat anti Human Kappa Chain (Fab'2) (HRP)

MBS536358-5x1mg 5x1mg
EUR 4415

Goat anti Human Kappa Chain (Fab'2) (FITC)

43C-CJ0130 1 mg
EUR 382
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2) (FITC)

Goat anti Human Kappa Chain (Fab'2) (FITC)

MBS538823-1mg 1mg
EUR 710

Goat anti Human Kappa Chain (Fab'2) (FITC)

MBS538823-5x1mg 5x1mg
EUR 3045

Goat Fab'2 Anti-Mouse kappa (kappa chain) LE/AF Antibody

MBS4151523-01mg 0.1mg
EUR 760

Goat Fab'2 Anti-Mouse kappa (kappa chain) LE/AF Antibody

MBS4151523-5x01mg 5x0.1mg
EUR 3170

Goat Anti-Human Kappa-AP

MBS674638-1mL 1mL
EUR 255

Goat Anti-Human Kappa-AP

MBS674638-5x1mL 5x1mL
EUR 995

Goat Anti-Human Kappa-PE

MBS674643-05mg 0.5mg
EUR 450

Goat Anti-Human Kappa-PE

MBS674643-5x05mg 5x0.5mg
EUR 1880

Goat Anti-Human Kappa-HRP

MBS674639-1mL 1mL
EUR 240

Goat Anti-Human Kappa-HRP

MBS674639-5x1mL 5x1mL
EUR 935

Goat Anti-Human Kappa-UNLB

MBS674635-1mg 1mg
EUR 220

Goat Anti-Human Kappa-UNLB

MBS674635-5x1mg 5x1mg
EUR 835

Goat Anti-Human Kappa-FITC

MBS674636-1mg 1mg
EUR 245

Goat Anti-Human Kappa-FITC

MBS674636-5x1mg 5x1mg
EUR 955

Goat Anti-Human Kappa-BGAL

MBS674640-1mL 1mL
EUR 245

Goat Anti-Human Kappa-BGAL

MBS674640-5x1mL 5x1mL
EUR 960

Goat Anti-Human Kappa-TXRD

MBS674641-1mg 1mg
EUR 245

Goat Anti-Human Kappa-TXRD

MBS674641-5x1mg 5x1mg
EUR 955

Goat Anti-Human Kappa-BIOT

MBS674642-1mg 1mg
EUR 245

Goat Anti-Human Kappa-BIOT

MBS674642-5x1mg 5x1mg
EUR 955

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MBS674637-1mg 1mg
EUR 245

Goat Anti-Human Kappa-TRITC

MBS674637-5x1mg 5x1mg
EUR 955

GOAT F(ab')2 ANTI HUMAN KAPPA LIGHT CHAIN

MBS222994-05mg 0.5mg
EUR 290

GOAT F(ab')2 ANTI HUMAN KAPPA LIGHT CHAIN

MBS222994-5x05mg 5x0.5mg
EUR 1135

GOAT ANTI HUMAN KAPPA LIGHT CHAIN (MOUSE ADSORBED)

MBS223487-1mg 1mg
EUR 460

GOAT ANTI HUMAN KAPPA LIGHT CHAIN (MOUSE ADSORBED)

MBS223487-5x1mg 5x1mg
EUR 1890

GOAT F(ab')2 ANTI HUMAN KAPPA LIGHT CHAIN:HRP

MBS222995-1mL 1mL
EUR 370

GOAT F(ab')2 ANTI HUMAN KAPPA LIGHT CHAIN:HRP

MBS222995-5x1mL 5x1mL
EUR 1500

GOAT F(ab')2 ANTI HUMAN KAPPA LIGHT CHAIN:RPE

MBS222996-05mL 0.5mL
EUR 490

GOAT F(ab')2 ANTI HUMAN KAPPA LIGHT CHAIN:RPE

MBS222996-5x05mL 5x0.5mL
EUR 2030

Goat anti Human Kappa Chain (Fab'2) (Texas Red)

43C-CJ0131 1 mg
EUR 382
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2)

Goat anti Human Kappa Chain (Fab'2) (Texas Red)

MBS538824-1mg 1mg
EUR 710

Goat anti Human Kappa Chain (Fab'2) (Texas Red)

MBS538824-5x1mg 5x1mg
EUR 3045

GOAT F(ab')2 ANTI HUMAN KAPPA LIGHT CHAIN:Biotin

MBS224089-05mg 0.5mg
EUR 345

GOAT F(ab')2 ANTI HUMAN KAPPA LIGHT CHAIN:Biotin

MBS224089-5x05mg 5x0.5mg
EUR 1375

Goat Anti Human IgG Kappa Polyclonal Affinity Purified

IGTAHUIGGKAP1MG each
EUR 209
Description: Goat Anti Human IgG Kappa Polyclonal Affinity Purified

Goat Anti Human IgG Kappa Polyclonal Affinity Purified

MBS136510-1mg 1mg
EUR 325

Goat Anti Human IgG Kappa Polyclonal Affinity Purified

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OATA01333-500UG - Goat Anti-Human Kappa Light Chain Antibody : HRP

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EUR 339

Goat anti Human Ig kappa light chain (free and bound)

MBS571235-1mL 1mL
EUR 365

Goat anti Human Ig kappa light chain (free and bound)

MBS571235-5x1mL 5x1mL
EUR 1490

Goat anti human Ig kappa light chain (free and bound)

MBS571413-1mL 1mL
EUR 395

Goat anti human Ig kappa light chain (free and bound)

MBS571413-5x1mL 5x1mL
EUR 1625

Goat anti Human Ig kappa light chain (free and bound)

MBS571420-10mg 10mg
EUR 430

Goat anti Human Ig kappa light chain (free and bound)

MBS571420-5x10mg 5x10mg
EUR 1775

Goat anti Human Ig kappa light chains (free and bound)

MBS571682-10mg 10mg
EUR 625

Goat anti Human Ig kappa light chains (free and bound)

MBS571682-5x10mg 5x10mg
EUR 2665

Goat Anti-Human kappa ( chain specific)

GWB-3C23F5 0.5 mg Ask for price

Goat Anti-Human kappa ( chain specific)

GWB-507C8C 1 ml Ask for price

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GWB-5640C1 1 mg Ask for price

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GWB-5DBFEC 1 ml Ask for price

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GWB-628F17 1 mg Ask for price

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GWB-1C4FA1 1 mg Ask for price

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GWB-8C381A 1 mg Ask for price

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GWB-A70370 1 ml Ask for price

Goat anti Kappa Light Chain

MBS316083-10mL 10mL
EUR 385

Goat anti Kappa Light Chain

MBS316083-5x10mL 5x10mL
EUR 1570

Goat anti Kappa Light Chain

MBS316090-10mL 10mL
EUR 370

Goat anti Kappa Light Chain

MBS316090-5x10mL 5x10mL
EUR 1500

Goat Anti-Mouse Kappa-AP

MBS674433-1mL 1mL
EUR 320

Goat Anti-Mouse Kappa-AP

MBS674433-5x1mL 5x1mL
EUR 1295

Goat Anti-Mouse Kappa-PE

MBS674437-05mg 0.5mg
EUR 395

Goat Anti-Mouse Kappa-PE

MBS674437-5x05mg 5x0.5mg
EUR 1630

Goat Anti-Mouse Kappa-HRP

LF-SA8066H 1.0 ml Ask for price
Description: Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa-HRP

MBS674434-1mL 1mL
EUR 285

Goat Anti-Mouse Kappa-HRP

MBS674434-5x1mL 5x1mL
EUR 1135

Goat Anti-Mouse Kappa-UNLB

MBS674430-1mg 1mg
EUR 275

Goat Anti-Mouse Kappa-UNLB

MBS674430-5x1mg 5x1mg
EUR 1095

Goat Anti-Mouse Kappa-FITC

MBS674431-1mg 1mg
EUR 310

Goat Anti-Mouse Kappa-FITC

MBS674431-5x1mg 5x1mg
EUR 1240
SD rats fed unusual eating regimen had been set as regular management teams. 20 rats, 20 within the simvastatin group and 20 within the simvastatin nanocarrier group. After 5 weeks of drug intervention, the rats had been sacrificed and the aorta was taken to find out the sleek muscle cell apoptosis charge. Research have proven that simvastatin nanocarriers can extra successfully scale back blood lipids in hyperlipidemia rats, enhance the speed of clean muscle cell apoptosis in hyperlipidemia rats, and delay the onset of atherosclerosis.

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