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Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells

Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells
Posted by Nicole

Since ZIKV was first detected at Uganda in 1947 and, severe outbreaks have globally occurred within the Yap Island, the French Polynesia and Brazil. Although the variety of an infection and unfold of ZIKV have sharply rise, the pathogenesis or replication mechanisms ZIKV haven’t been properly studied. Zika virus (ZIKV) is lately highlighted Flavivirus, a mosquito born rising virus inflicting microcephaly and the Guillain-Barre syndrome in fetuses and adults, respectively. ZIKV polyprotein consists of three structural proteins named C, prM and E and 7 nonstructural proteins named NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 in 11-kb single-stranded constructive sense RNA genome. The perform of particular person ZIKV genes on the host innate immune responses have been barely studied.

On this research, we investigated the modulations of the NF-κB promoter exercise associated by the MDA5/RIG-I signaling pathway. Within the outcomes, two nonstructural proteins, NS2A and NS4A, dramatically suppressed the NF-κB promoter exercise by inhibiting signaling elements on MDA5/RIG-I signaling pathway associated to activation of NF-κB. Apparently, NS2A suppressed all parts of MDA5/RIG-I signaling pathway, however NS4A inhibited most signaling molecules, besides IKKε and IRF3-5D. As well as, each NS2A and NS4A down-regulated MDA5 associated NF-κB promoter exercise in dose-dependent method. Taken collectively, our outcomes introduced that NS2A and NS4A critically antagonize MDA5/RIG-I-mediated NF-κB manufacturing and people proteins could appear to be managed in several mechanisms. This research might assist perceive the mechanisms how ZIKV controls innate immune responses and could also be supplied for improvement of ZIKV-specific medicines.

 

 

Cytochrome P450 1A2 overcomes nuclear issue kappa B-mediated sorafenib resistance in hepatocellular carcinoma

Sorafenib resistance has grow to be the primary impediment within the efficient therapy of superior hepatocellular carcinoma (HCC) sufferers. Activation of nuclear issue kappa B (NF-κB) is a newly recognized mechanism that contributes to desensitized sorafenib. Cytochrome P450 1A2 (CYP1A2) capabilities as a tumor suppressor in HCC and its expression is negatively related to NF-κB within the liver. This research aimed to check whether or not CYP1A2 might overcome sorafenib resistance. To analyze whether or not CYP1A2 and NF-κB p65 performed roles in sorafenib desensitization, we established sorafenib-resistant (SR) HCC cells.
SR cells decreased the expression of CYP1A2 together with the upregulation of NF-κB p65. CYP1A2 overexpression attenuated SR cell proliferation, elevated sorafenib sensitivity, and inhibited the NF-κB pathway, whereas CYP1A2 silence confirmed reverse results. Sorafenib, together with omeprazole, a CYP1A2 inducer, considerably hindered the expansion and invasion of SR cells in vitro in addition to decreased the tumor development in vivo. The mixture therapy markedly elevated CYP1A2 expression and inhibited the sorafenib-induced NF-κB signaling. As well as, the overexpression of NF-κB p65 stimulated the SR cell development and desensitized sorafenib in SR cells, the place CYP1A2 overexpression reversed the phenomenon. Lastly, nearly all of HCC tissue samples displayed decreased CYP1A2 however elevated NF-κB p65 protein expression. Collectively, CYP1A2 can sensitize SR cells to sorafenib by way of inhibiting NF-κB p65 axis. Omeprazole together with sorafenib exerts a synergistic impact in assuaging acquired sorafenib resistance.
 Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells
Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells

Nuclear issue erythroid 2-related issue 2 (Nrf2) as a possible therapeutic goal for vitiligo

Vitiligo is an autoimmune illness of the pores and skin which causes lack of melanocytes from the dermis. Not too long ago, it’s demonstrated that oxidative stress (OS) performs a big function within the immuno-pathogenesis of vitiligo. A serious mechanism within the mobile protection in opposition to OS is activation of the nuclear issue erythroid2-related issue (Nrf2)-Kelch-like ECH-associated protein 1(Keap1)-antioxidant responsive aspect (ARE) signaling pathway. Not too long ago it has been proven that vitiligo melanocytes have impaired Nrf2-ARE signaling. Plenty of medicine together with these often called Nrf2 activators and people identified to own results to activate Nrf2, have been utilized in treating vitiligo with sure therapeutic results.
Additionally, research have proven that quite a lot of compounds can shield melanocytes in opposition to OS by way of activating Nrf2. These compounds could also be thought of as candidates for creating new medicine for vitiligo sooner or later. Nrf2 might be thought of as a possible therapeutic goal for vitiligo. This text ready a simvastatin-NLCs for the therapy of arteriosclerotic occlusive illness of decrease limbs. Taking the scale distribution, polydispersity coefficient, encapsulation effectivity and drug loading of simvastatin-NLCs as analysis indicators, numerous prescription elements of simvastatin- NLCs had been investigated. The in vitro launch conduct and stability of simvastatin-NLCs had been additionally investigated. A hyperlipidemia rat mannequin was established utilizing high-fat diets.

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

Goat Anti-Mouse Kappa antibody (AU)

STJ99353-100l 100 µl
EUR 214.8
Description: AU conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (AU)

STJ99353-1mL 1 mL
EUR 1198.8
Description: AU conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (Biotin)

STJ99403-100l 100 µl
EUR 214.8
Description: Biotin conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (Biotin)

STJ99403-1mL 1 mL
EUR 1198.8
Description: Biotin conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (FITC)

STJ99453-100l 100 µl
EUR 214.8
Description: FITC conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (FITC)

STJ99453-1mL 1 mL
EUR 1198.8
Description: FITC conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (HRP)

STJ99503-100l 100 µl
EUR 214.8
Description: HRP conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (HRP)

STJ99503-1mL 1 mL
EUR 1198.8
Description: HRP conjugated Goat polyclonal to Mouse Kappa

Goat anti Human Kappa Chain (FITC)

43C-CB9122 1 mg
EUR 433.2
Description: Goat anti Human Kappa Chain secondary antibody (FITC)

Goat anti Human Kappa Chain (rhodamine)

43C-CB9123 1 mg
EUR 433.2
Description: Goat anti Human Kappa Chain secondary antibody (Rhodamine)

Goat anti Human Kappa Chain (biotin)

43C-CB9125 1 mg
EUR 460.8
Description: Goat anti Human Kappa Chain secondary antibody (biotin)

Goat anti Human Kappa Chain (HRP)

43C-CB9126 1 mg
EUR 475.2
Description: Goat anti Human Kappa Chain secondary antibody (HRP)

Goat anti Human kappa chain (biotin)

43R-1258 500 ug
EUR 447.6
Description: Goat anti Human kappa chain secondary antibody (biotin)

Goat anti Human kappa chain (FITC)

43R-1259 500 ug
EUR 420
Description: Goat anti Human kappa chain secondary antibody (FITC)

Goat anti Human kappa chain (HRP)

43R-1260 500 ug
EUR 429.6
Description: Goat anti Human kappa chain secondary antibody (HRP)

Goat anti Human kappa chain (rhodamine)

43R-1261 500 ug
EUR 420
Description: Goat anti Human kappa chain secondary antibody (rhodamine)

Goat anti Human kappa chain (biotin)

43R-1264 500 ug
EUR 528
Description: Goat anti Human kappa chain secondary antibody (biotin)

Goat anti Human kappa chain (FITC)

43R-1265 500 ug
EUR 482.4
Description: Goat anti Human kappa chain secondary antibody (FITC)

Goat anti Human kappa chain (HRP)

43R-1266 500 ug
EUR 505.2
Description: Goat anti Human kappa chain secondary antibody (HRP)

Goat anti Human Kappa light chain

20-S2301G000-S4 10 ml
EUR 165.6
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2301G000-V0 10 ml
EUR 133.2
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2501G000-V0 10 ml
EUR 178.8
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2503GND1-D0 5 ml
EUR 230.4
Description: Goat anti Human Kappa light chain antibody

Goat Anti-Mouse Kappa-HRP

LF-SA8066H 1.0 ml Ask for price
Description: Goat polyclonal to Mouse Kappa

Goat Anti Human Kappa Light Chain Polyclonal Antibody

CPBT-65574GH 1 mg
EUR 696

Goat Anti Human Kappa Light Chain Polyclonal Antibody

CPBT-65580GH 1 ml
EUR 514.8

Goat anti Human Kappa Chain (Texas Red)

43C-CB9124 1 mg
EUR 433.2
Description: Goat anti Human Kappa Chain secondary antibody

Goat anti Human Kappa Chain (Alk Phos)

43C-CB9127 1 mg
EUR 500.4
Description: Goat anti Human Kappa Chain secondary antibody (Alk Phos)

Goat anti Human kappa chain (Alk Phos)

43R-1257 500 ug
EUR 482.4
Description: Goat anti Human kappa chain secondary antibody (Alk Phos)

Goat anti Human Kappa Chain (Fab'2)

41C-CJ0129 1 mg
EUR 406.8
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2)

Goat anti Human Kappa + Lambda light chain

20-S1701G000-V0 10 ml
EUR 165.6
Description: Goat anti Human kappa + lambda light chain secondary antibody

Goat Anti Human Kappa Light Chain Polyclonal Antibody,FITC

CPBT-65572GH 1 mg
EUR 696

Goat Anti Human Kappa Light Chain Polyclonal Antibody,HRP

CPBT-65573GH 1 ml
EUR 696

Goat anti Mouse Kappa Light Chain

70R-KG001 1 ml
EUR 289.2
Description: Affinity purified Goat anti Mouse Kappa Light Chain antibody

HRP*Polyclonal Goat Anti-Mouse Kappa

C030214-101ml 10.1ml
EUR 272.4

HRP*Polyclonal Goat Anti-Mouse Kappa

C030214-1ml 1ml
EUR 1134

FITC*Polyclonal Goat Anti-Mouse Kappa

C030614-101ml 10.1ml
EUR 272.4

FITC*Polyclonal Goat Anti-Mouse Kappa

C030614-1ml 1ml
EUR 1134

BIOTIN*Polyclonal Goat Anti-Mouse Kappa

C030814-101ml 10.1ml
EUR 272.4

BIOTIN*Polyclonal Goat Anti-Mouse Kappa

C030814-1ml 1ml
EUR 1134

Goat anti Human Kappa Chain (Fab'2) (FITC)

43C-CJ0130 1 mg
EUR 462
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2) (FITC)

Goat anti Human Kappa Chain (Fab'2) (HRP)

43C-CJ0132 1 mg
EUR 546
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2) (HRP)

Anti-Kappa antibody

STJ160049 1 mL C
EUR 282
Description: Anti-Kappa recognizes surface immunoglobulin on normal and neoplastic B-cells, and has been indicated as a potential aid in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas, where the expression of a single light chain class is restricted. The determination of light chain ratio is critical in evaluating B-cell neoplasms, as the majority of B-cell lymphomas express either kappa or lambda light chains, while a mixture of kappa and lambda is characteristic of reactive proliferations. In paraffin-embedded tissue, Anti-Kappa displays strong staining of kappa-positive plasma cells, as well as cells that have absorbed exogenous immunoglobulins.

Anti-Kappa antibody

STJ180139 0.1 ml
EUR 254.4

Anti-Kappa antibody

STJ180388 0.1 ml
EUR 254.4

Goat anti Mouse Kappa Light Chain (HRP)

60R-KG001hrp 1 ml
EUR 548.4
Description: Goat anti Mouse Kappa Light Chain secondary antibody (HRP)

Goat anti Human Kappa Chain (Fab'2) (Texas Red)

43C-CJ0131 1 mg
EUR 466.8
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2)

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

DLR-GOAT-Hu-48T 48T
EUR 664.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Ghrelin-O-Acyltransferase (GOAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

DLR-GOAT-Hu-96T 96T
EUR 870
Description: A sandwich quantitative ELISA assay kit for detection of Human Ghrelin-O-Acyltransferase (GOAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RDR-GOAT-Hu-48Tests 48 Tests
EUR 706.8

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RDR-GOAT-Hu-96Tests 96 Tests
EUR 984

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RD-GOAT-Hu-48Tests 48 Tests
EUR 675.6

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RD-GOAT-Hu-96Tests 96 Tests
EUR 939.6

Kappa; Clone L1C1 (Ready-To-Use)

A00113-0002 2 ml
EUR 82.8

Kappa; Clone L1C1 (Ready-To-Use)

A00113-0007 7 ml
EUR 114

Kappa; Clone L1C1 (Ready-To-Use)

A00113-0025 25 ml
EUR 225.6

OR Antibody

44609-100ul 100ul
EUR 302.4

OR Antibody

44609-50ul 50ul
EUR 224.4

OR Antibody

ABD10250 100 ug
EUR 525.6

OR Antibody

20-abx217389
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

OR Antibody

DF10250 200ul
EUR 420

Anti-PP2C kappa Antibody

A04319 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for PP2C kappa Antibody (PPM1K) detection.tested for WB in Human.

Anti-Actin- kappa Antibody

A14672-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Actin- kappa Antibody (ACTBL2) detection. Tested with WB in Human, Mouse.

Anti-immunoglobulin kappa antibody

PAab04295 100 ug
EUR 463.2

anti- immunoglobulin kappa antibody

FNab04295 100µg
EUR 658.5
Description: Antibody raised against immunoglobulin kappa

Anti-Actin-kappa antibody

STJ91470 200 µl
EUR 236.4
Description: Rabbit polyclonal to Actin-kappa.

Anti-DGK-kappa antibody

STJ92704 200 µl
EUR 236.4
Description: Rabbit polyclonal to DGK-kappa.

Anti-kappa-alpha antibody

STJ93782 200 µl
EUR 236.4
Description: IkappaB-alpha is a protein encoded by the NFKBIA gene which is approximately 35,6 kDa. IkappaB-alpha is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the TNFR1 pathway, 4-1BB pathway and toll-like receptor signalling pathways. This protein falls under the NF-kappa-B inhibitor family. It inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses it becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. IkappaB-alpha is expressed in adherent monocytes. Mutations in the NFKBIA gene may result in ectodermal dysplasia and leukorrhea. STJ93782 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of IkappaB-alpha protein.

Anti-kappa-alpha antibody

STJ93783 200 µl
EUR 236.4
Description: Rabbit polyclonal to IkappaB-alpha.

Anti-kappa-alpha antibody

STJ93784 200 µl
EUR 236.4
Description: Rabbit polyclonal to IkappaB-alpha.

Anti-kappa-alpha antibody

STJ93785 200 µl
EUR 236.4
Description: Rabbit polyclonal to IkappaB-alpha.

Anti-kappa-beta antibody

STJ93786 200 µl
EUR 236.4
Description: Rabbit polyclonal to IkappaB-beta.

Anti-kappa-epsilon antibody

STJ93787 200 µl
EUR 236.4
Description: Rabbit polyclonal to IkappaB-epsilon.

Anti-NF kappa antibody

STJ94454 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFRkappaB.

Anti-kappa-beta antibody

STJ98186 100 µl
EUR 280.8
Description: Mouse monoclonal to IkappaB-beta.

Anti-kappa-alpha antibody

STJ98512 100 µl
EUR 280.8
Description: Mouse monoclonal to IkappaB-alpha.

Anti-PP2 kappa antibody

STJ95197 200 µl
EUR 236.4
Description: Rabbit polyclonal to PP2Ckappa.

Anti-kappa-alpha antibody

STJ97440 200 µl
EUR 236.4
Description: Rabbit polyclonal to IkappaB-alpha.

Anti-kappa beta antibody

STJ97539 200 µl
EUR 236.4
Description: IkappaB beta is a protein encoded by the NFKBIB gene which is approximately 37,7 kDa. IkappaB beta is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, toll-like receptor signalling pathways and the 4-1BB pathway. This protein falls under the NF-kappa-B inhibitor family, which inhibits NF-kappa-B by complexing with it and trapping it in the cytoplasm. Phosphorylation of serine residues on the protein marks it for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which then translocates to the nucleus to function as a transcription factor. IkappaB beta is expressed in the liver, lung, pancreas, nervous system and blood. STJ97539 was developed from clone 1F3 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of IkappaB beta.

Anti-kappa beta antibody

STJ97540 200 µl
EUR 236.4
Description: Mouse monoclonal to IkappaB beta (8D11).

Mouse Anti-Human Ig Kappa antibody

STJ99554-100l 100 µl
EUR 109.2
Description: Unconjugated Mouse monoclonal to Human Ig Kappa antibody

Mouse Anti-Human Ig Kappa antibody

STJ99554-1mL 1 mL
EUR 616.8
Description: Unconjugated Mouse monoclonal to Human Ig Kappa antibody

Anti-Human kappa light chain antibody

STJ16100578 1 mL
EUR 348

Polyclonal Goat Anti-GOT2 (aa 295 to 306) Antibody

AMM04997G 0.1 mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-GOT2 (aa 295 to 306) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-GOT2 (aa 360 to 373) Antibody

AMM04998G 0.1 mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-GOT2 (aa 360 to 373) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-Renalase (aa 134 to 147) Antibody

AMM05956G 0.1 mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Renalase (aa 134 to 147) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-Renalase (aa 224 to 233) Antibody

APG03367G 0.1 mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Renalase (aa 224 to 233) . This antibody is tested and proven to work in the following applications:

Goat F(Ab')2 Anti Human Kappa Light Chain Polyclonal Antibody,Biotin

CPBT-65575GA 0.5 mg
EUR 696

Goat F(Ab')2 Anti Human Kappa Light Chain Polyclonal Antibody,RPE

CPBT-65578GA 0.5 ml
EUR 696

Goat IgG Secondary antibody Clone: pAb to UltraPolymer Goat Anti-Human IgG (H&L) HRP

A1278-15 15 ml
EUR 386.4
Description: Goat IgG Secondary antibody Clone: pAb against UltraPolymer Goat Anti-Human IgG (H&L) HRPfor application in IHC.The immunogen is Human IgG (H&L).This antibody can be used for detection of the target molecule in samples from Human.

Goat IgG Secondary antibody Clone: pAb to UltraPolymer Goat Anti-Human IgG (H&L) HRP

A1278-5 5 ml
EUR 198
Description: Goat IgG Secondary antibody Clone: pAb against UltraPolymer Goat Anti-Human IgG (H&L) HRPfor application in IHC.The immunogen is Human IgG (H&L).This antibody can be used for detection of the target molecule in samples from Human.

Goat Anti-human Kappa light chain (bound and free)-HRP conjugate

MKUL11-HRP 0.5ml
EUR 255.6

Anti-Opioid Receptor κ Antibody

A02906 100ug
EUR 487.2
Description: Rabbit Polyclonal Opioid Receptor κ Antibody. Validated in ELISA, WB and tested in Human, Mouse, Rat.

Anti-PPM1K/Pp2C Kappa Antibody

A04319-1 100ul
EUR 476.4
Description: Rabbit Polyclonal PPM1K/Pp2C Kappa Antibody. Validated in IHC, WB and tested in Human, Mouse.

Anti-N kappa-p100 antibody

STJ94458 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p100.

Anti-N kappa-p100 antibody

STJ94459 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p100.

Anti-N kappa-p105 antibody

STJ94460 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94461 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94462 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94463 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94464 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p65 antibody

STJ94467 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94468 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94469 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94470 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94471 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94472 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94473 200 µl
EUR 236.4
Description: NFkappaB-p65 is a protein encoded by the RELA gene which is approximately 60,2 kDa. NFkappaB-p65 is localised to the nucleus and cytoplasm. It is involved in activated TLR4 signalling, toll-like receptor signalling pathways, cytosolic sensors of pathogen-associated DNA and immune response. NF-kappa-B is a transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NFkappaB-p65 is expressed in the nervous system, intestine, bone, lung and skin. Mutations in the RELA gene result in Ependymoma, Reticuloendotheliosis and Retinitis Pigmentosa-50. STJ94473 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of NFkappaB-p65 protein.

Anti-N kappa-p65 antibody

STJ94474 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94475 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94476 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94477 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ98276 100 µl
EUR 280.8
Description: Mouse monoclonal to NFkappaB-p65.

Anti-NF-kappa p65 antibody

STJ98601 200 µl
EUR 236.4
Description: Rabbit polyclonal to NF-kappaB p65.

Anti-N kappa-p105 antibody

STJ96474 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p65 antibody

STJ96703 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ96704 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ96793 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-Kappa Light Chains antibody

STJ16100380 1 mL
EUR 592.8

Anti-Mouse-IgG2a Kappa antibody

STJ16100662 1 mL
EUR 1786.8

Anti-Mouse-IgG2a Kappa antibody

STJ16100663 1 mL
EUR 1045.2

Anti-Kappa Light Chain antibody

STJ16100959 100 tests
EUR 628.8

Anti-Kappa Light Chain antibody

STJ16101014 100 µg
EUR 424.8

Vortex mixer 32x microtubes or 1x up to 15ml

MIX3200 EACH
EUR 402.42

Polyclonal Goat Anti-BDH2 / DHRS6 (aa 60 to 71) Antibody

AMM04910G 0.1 mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-BDH2 / DHRS6 (aa 60 to 71) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-C2GnT-M (aa 273 to 284) Antibody

APR16228G 0.1 mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-C2GnT-M (aa 273 to 284) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-C2GnT-M (aa 410 to 422) Antibody

APR16229G 0.1 mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-C2GnT-M (aa 410 to 422) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-EPB41L2 / 4.1G (aa 593 to 604) Antibody

APG00100G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-EPB41L2 / 4.1G (aa 593 to 604) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-TUSC4 / NPRL2 (aa 140 to 151) Antibody

APG00353G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-TUSC4 / NPRL2 (aa 140 to 151) . This antibody is tested and proven to work in the following applications:

Mouse anti Human IgG Kappa

40R-1013 500 ug
EUR 678
Description: Mouse anti Human IgG Kappa Light Chain secondary antibody

Anti-Human Kappa Light Chain

DB-037-0.1 100 μl
EUR 254.4
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human Kappa Light Chain

DB-037-0.2 200 μl
EUR 357.6
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human Kappa Light Chain

DB-037-0.5 500 μl
EUR 460.8
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human Kappa Light Chain

DB-037-1 1 ml
EUR 735.6
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human Kappa Light Chain

DB-037-RTU-15 15 ml
EUR 424.8
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human Kappa Light Chain

DB-037-RTU-7 7 ml
EUR 277.2
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human Kappa Light Chain

DB-038-0.1 100 μl
EUR 254.4
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human Kappa Light Chain

DB-038-0.2 200 μl
EUR 357.6
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human Kappa Light Chain

DB-038-0.5 500 μl
EUR 460.8
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human Kappa Light Chain

DB-038-1 1 ml
EUR 735.6
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated
SD rats fed unusual eating regimen had been set as regular management teams. 20 rats, 20 within the simvastatin group and 20 within the simvastatin nanocarrier group. After 5 weeks of drug intervention, the rats had been sacrificed and the aorta was taken to find out the sleek muscle cell apoptosis charge. Research have proven that simvastatin nanocarriers can extra successfully scale back blood lipids in hyperlipidemia rats, enhance the speed of clean muscle cell apoptosis in hyperlipidemia rats, and delay the onset of atherosclerosis.

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