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Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells

Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells
Posted by Nicole

Since ZIKV was first detected at Uganda in 1947 and, severe outbreaks have globally occurred within the Yap Island, the French Polynesia and Brazil. Although the variety of an infection and unfold of ZIKV have sharply rise, the pathogenesis or replication mechanisms ZIKV haven’t been properly studied. Zika virus (ZIKV) is lately highlighted Flavivirus, a mosquito born rising virus inflicting microcephaly and the Guillain-Barre syndrome in fetuses and adults, respectively. ZIKV polyprotein consists of three structural proteins named C, prM and E and 7 nonstructural proteins named NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 in 11-kb single-stranded constructive sense RNA genome. The perform of particular person ZIKV genes on the host innate immune responses have been barely studied.

On this research, we investigated the modulations of the NF-κB promoter exercise associated by the MDA5/RIG-I signaling pathway. Within the outcomes, two nonstructural proteins, NS2A and NS4A, dramatically suppressed the NF-κB promoter exercise by inhibiting signaling elements on MDA5/RIG-I signaling pathway associated to activation of NF-κB. Apparently, NS2A suppressed all parts of MDA5/RIG-I signaling pathway, however NS4A inhibited most signaling molecules, besides IKKε and IRF3-5D. As well as, each NS2A and NS4A down-regulated MDA5 associated NF-κB promoter exercise in dose-dependent method. Taken collectively, our outcomes introduced that NS2A and NS4A critically antagonize MDA5/RIG-I-mediated NF-κB manufacturing and people proteins could appear to be managed in several mechanisms. This research might assist perceive the mechanisms how ZIKV controls innate immune responses and could also be supplied for improvement of ZIKV-specific medicines.

 

 

Cytochrome P450 1A2 overcomes nuclear issue kappa B-mediated sorafenib resistance in hepatocellular carcinoma

Sorafenib resistance has grow to be the primary impediment within the efficient therapy of superior hepatocellular carcinoma (HCC) sufferers. Activation of nuclear issue kappa B (NF-κB) is a newly recognized mechanism that contributes to desensitized sorafenib. Cytochrome P450 1A2 (CYP1A2) capabilities as a tumor suppressor in HCC and its expression is negatively related to NF-κB within the liver. This research aimed to check whether or not CYP1A2 might overcome sorafenib resistance. To analyze whether or not CYP1A2 and NF-κB p65 performed roles in sorafenib desensitization, we established sorafenib-resistant (SR) HCC cells.
SR cells decreased the expression of CYP1A2 together with the upregulation of NF-κB p65. CYP1A2 overexpression attenuated SR cell proliferation, elevated sorafenib sensitivity, and inhibited the NF-κB pathway, whereas CYP1A2 silence confirmed reverse results. Sorafenib, together with omeprazole, a CYP1A2 inducer, considerably hindered the expansion and invasion of SR cells in vitro in addition to decreased the tumor development in vivo. The mixture therapy markedly elevated CYP1A2 expression and inhibited the sorafenib-induced NF-κB signaling. As well as, the overexpression of NF-κB p65 stimulated the SR cell development and desensitized sorafenib in SR cells, the place CYP1A2 overexpression reversed the phenomenon. Lastly, nearly all of HCC tissue samples displayed decreased CYP1A2 however elevated NF-κB p65 protein expression. Collectively, CYP1A2 can sensitize SR cells to sorafenib by way of inhibiting NF-κB p65 axis. Omeprazole together with sorafenib exerts a synergistic impact in assuaging acquired sorafenib resistance.
 Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells
Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells

Nuclear issue erythroid 2-related issue 2 (Nrf2) as a possible therapeutic goal for vitiligo

Vitiligo is an autoimmune illness of the pores and skin which causes lack of melanocytes from the dermis. Not too long ago, it’s demonstrated that oxidative stress (OS) performs a big function within the immuno-pathogenesis of vitiligo. A serious mechanism within the mobile protection in opposition to OS is activation of the nuclear issue erythroid2-related issue (Nrf2)-Kelch-like ECH-associated protein 1(Keap1)-antioxidant responsive aspect (ARE) signaling pathway. Not too long ago it has been proven that vitiligo melanocytes have impaired Nrf2-ARE signaling. Plenty of medicine together with these often called Nrf2 activators and people identified to own results to activate Nrf2, have been utilized in treating vitiligo with sure therapeutic results.
Additionally, research have proven that quite a lot of compounds can shield melanocytes in opposition to OS by way of activating Nrf2. These compounds could also be thought of as candidates for creating new medicine for vitiligo sooner or later. Nrf2 might be thought of as a possible therapeutic goal for vitiligo. This text ready a simvastatin-NLCs for the therapy of arteriosclerotic occlusive illness of decrease limbs. Taking the scale distribution, polydispersity coefficient, encapsulation effectivity and drug loading of simvastatin-NLCs as analysis indicators, numerous prescription elements of simvastatin- NLCs had been investigated. The in vitro launch conduct and stability of simvastatin-NLCs had been additionally investigated. A hyperlipidemia rat mannequin was established utilizing high-fat diets.

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Goat Anti-Mouse Kappa antibody (AU)

STJ99353-100l 100 µl
EUR 179
Description: AU conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (AU)

STJ99353-1mL 1 mL
EUR 999
Description: AU conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (Biotin)

STJ99403-100l 100 µl
EUR 179
Description: Biotin conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (Biotin)

STJ99403-1mL 1 mL
EUR 999
Description: Biotin conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (FITC)

STJ99453-100l 100 µl
EUR 179
Description: FITC conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (FITC)

STJ99453-1mL 1 mL
EUR 999
Description: FITC conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (HRP)

STJ99503-100l 100 µl
EUR 179
Description: HRP conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (HRP)

STJ99503-1mL 1 mL
EUR 999
Description: HRP conjugated Goat polyclonal to Mouse Kappa

Goat anti Human Kappa Chain (FITC)

43C-CB9122 1 mg
EUR 361
Description: Goat anti Human Kappa Chain secondary antibody (FITC)

Goat anti Human Kappa Chain (rhodamine)

43C-CB9123 1 mg
EUR 361
Description: Goat anti Human Kappa Chain secondary antibody (Rhodamine)

Goat anti Human Kappa Chain (biotin)

43C-CB9125 1 mg
EUR 384
Description: Goat anti Human Kappa Chain secondary antibody (biotin)

Goat anti Human Kappa Chain (HRP)

43C-CB9126 1 mg
EUR 396
Description: Goat anti Human Kappa Chain secondary antibody (HRP)

Goat anti Human kappa chain (biotin)

43R-1258 500 ug
EUR 373
Description: Goat anti Human kappa chain secondary antibody (biotin)

Goat anti Human kappa chain (FITC)

43R-1259 500 ug
EUR 350
Description: Goat anti Human kappa chain secondary antibody (FITC)

Goat anti Human kappa chain (HRP)

43R-1260 500 ug
EUR 358
Description: Goat anti Human kappa chain secondary antibody (HRP)

Goat anti Human kappa chain (rhodamine)

43R-1261 500 ug
EUR 350
Description: Goat anti Human kappa chain secondary antibody (rhodamine)

Goat anti Human kappa chain (biotin)

43R-1264 500 ug
EUR 440
Description: Goat anti Human kappa chain secondary antibody (biotin)

Goat anti Human kappa chain (FITC)

43R-1265 500 ug
EUR 402
Description: Goat anti Human kappa chain secondary antibody (FITC)

Goat anti Human kappa chain (HRP)

43R-1266 500 ug
EUR 421
Description: Goat anti Human kappa chain secondary antibody (HRP)

Goat anti Human Kappa light chain

20-S2301G000-S4 10 ml
EUR 138
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2301G000-V0 10 ml
EUR 111
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2501G000-V0 10 ml
EUR 149
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2503GND1-D0 5 ml
EUR 192
Description: Goat anti Human Kappa light chain antibody

Goat Anti-Mouse Kappa-HRP

LF-SA8066H 1.0 ml Ask for price
Description: Goat polyclonal to Mouse Kappa

Goat Anti Human Kappa Light Chain Polyclonal Antibody

CPBT-65574GH 1 mg
EUR 580

Goat Anti Human Kappa Light Chain Polyclonal Antibody

CPBT-65580GH 1 ml
EUR 429

Goat anti Human Kappa Chain (Fab'2)

41C-CJ0129 1 mg
EUR 339
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2)

Goat anti Human Kappa Chain (Texas Red)

43C-CB9124 1 mg
EUR 361
Description: Goat anti Human Kappa Chain secondary antibody

Goat anti Human Kappa Chain (Alk Phos)

43C-CB9127 1 mg
EUR 417
Description: Goat anti Human Kappa Chain secondary antibody (Alk Phos)

Goat anti Human kappa chain (Alk Phos)

43R-1257 500 ug
EUR 402
Description: Goat anti Human kappa chain secondary antibody (Alk Phos)

Goat anti Human Kappa + Lambda light chain

20-S1701G000-V0 10 ml
EUR 138
Description: Goat anti Human kappa + lambda light chain secondary antibody

HRP*Polyclonal Goat Anti-Mouse Kappa

C030214-101ml 10.1ml
EUR 227

HRP*Polyclonal Goat Anti-Mouse Kappa

C030214-1ml 1ml
EUR 945

FITC*Polyclonal Goat Anti-Mouse Kappa

C030614-101ml 10.1ml
EUR 227

FITC*Polyclonal Goat Anti-Mouse Kappa

C030614-1ml 1ml
EUR 945

BIOTIN*Polyclonal Goat Anti-Mouse Kappa

C030814-101ml 10.1ml
EUR 227

BIOTIN*Polyclonal Goat Anti-Mouse Kappa

C030814-1ml 1ml
EUR 945

Goat anti Mouse Kappa Light Chain

70R-KG001 1 ml
EUR 241
Description: Affinity purified Goat anti Mouse Kappa Light Chain antibody

Goat Anti Human Kappa Light Chain Polyclonal Antibody,FITC

CPBT-65572GH 1 mg
EUR 580

Goat Anti Human Kappa Light Chain Polyclonal Antibody,HRP

CPBT-65573GH 1 ml
EUR 580

Kappa; Clone L1C1 (Ready-To-Use)

A00113-0002 2 ml
EUR 69

Kappa; Clone L1C1 (Ready-To-Use)

A00113-0007 7 ml
EUR 95

Kappa; Clone L1C1 (Ready-To-Use)

A00113-0025 25 ml
EUR 188

Anti-Kappa antibody

STJ160049 1 mL C
EUR 235
Description: Anti-Kappa recognizes surface immunoglobulin on normal and neoplastic B-cells, and has been indicated as a potential aid in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas, where the expression of a single light chain class is restricted. The determination of light chain ratio is critical in evaluating B-cell neoplasms, as the majority of B-cell lymphomas express either kappa or lambda light chains, while a mixture of kappa and lambda is characteristic of reactive proliferations. In paraffin-embedded tissue, Anti-Kappa displays strong staining of kappa-positive plasma cells, as well as cells that have absorbed exogenous immunoglobulins.

Anti-Kappa antibody

STJ180139 0.1 ml
EUR 212

Anti-Kappa antibody

STJ180388 0.1 ml
EUR 212

Goat anti Human Kappa Chain (Fab'2) (FITC)

43C-CJ0130 1 mg
EUR 385
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2) (FITC)

Goat anti Human Kappa Chain (Fab'2) (HRP)

43C-CJ0132 1 mg
EUR 455
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2) (HRP)

Polyclonal Goat Anti-GOT2 (aa 295 to 306) Antibody

AMM04997G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-GOT2 (aa 295 to 306) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-GOT2 (aa 360 to 373) Antibody

AMM04998G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-GOT2 (aa 360 to 373) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-Renalase (aa 134 to 147) Antibody

AMM05956G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Renalase (aa 134 to 147) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-Renalase (aa 224 to 233) Antibody

APG03367G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Renalase (aa 224 to 233) . This antibody is tested and proven to work in the following applications:

Goat anti Mouse Kappa Light Chain (HRP)

60R-KG001hrp 1 ml
EUR 457
Description: Goat anti Mouse Kappa Light Chain secondary antibody (HRP)

Goat anti Human Kappa Chain (Fab'2) (Texas Red)

43C-CJ0131 1 mg
EUR 389
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2)

Anti-PP2C kappa Antibody

A04319 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PP2C kappa Antibody (PPM1K) detection.tested for WB in Human.

Anti-Actin- kappa Antibody

A14672-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Actin- kappa Antibody (ACTBL2) detection. Tested with WB in Human, Mouse.

Anti-kappa-alpha antibody

STJ97440 200 µl
EUR 197
Description: Rabbit polyclonal to IkappaB-alpha.

Anti-kappa beta antibody

STJ97539 200 µl
EUR 197
Description: IkappaB beta is a protein encoded by the NFKBIB gene which is approximately 37,7 kDa. IkappaB beta is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, toll-like receptor signalling pathways and the 4-1BB pathway. This protein falls under the NF-kappa-B inhibitor family, which inhibits NF-kappa-B by complexing with it and trapping it in the cytoplasm. Phosphorylation of serine residues on the protein marks it for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which then translocates to the nucleus to function as a transcription factor. IkappaB beta is expressed in the liver, lung, pancreas, nervous system and blood. STJ97539 was developed from clone 1F3 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of IkappaB beta.

Anti-kappa beta antibody

STJ97540 200 µl
EUR 197
Description: Mouse monoclonal to IkappaB beta (8D11).

Anti-kappa-beta antibody

STJ98186 100 µl
EUR 234
Description: Mouse monoclonal to IkappaB-beta.

Anti-kappa-alpha antibody

STJ98512 100 µl
EUR 234
Description: Mouse monoclonal to IkappaB-alpha.

Anti-Actin-kappa antibody

STJ91470 200 µl
EUR 197
Description: Rabbit polyclonal to Actin-kappa.

Anti-DGK-kappa antibody

STJ92704 200 µl
EUR 197
Description: Rabbit polyclonal to DGK-kappa.

Anti-kappa-alpha antibody

STJ93782 200 µl
EUR 197
Description: IkappaB-alpha is a protein encoded by the NFKBIA gene which is approximately 35,6 kDa. IkappaB-alpha is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the TNFR1 pathway, 4-1BB pathway and toll-like receptor signalling pathways. This protein falls under the NF-kappa-B inhibitor family. It inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses it becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. IkappaB-alpha is expressed in adherent monocytes. Mutations in the NFKBIA gene may result in ectodermal dysplasia and leukorrhea. STJ93782 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of IkappaB-alpha protein.

Anti-kappa-alpha antibody

STJ93783 200 µl
EUR 197
Description: Rabbit polyclonal to IkappaB-alpha.

Anti-kappa-alpha antibody

STJ93784 200 µl
EUR 197
Description: Rabbit polyclonal to IkappaB-alpha.

Anti-kappa-alpha antibody

STJ93785 200 µl
EUR 197
Description: Rabbit polyclonal to IkappaB-alpha.

Anti-kappa-beta antibody

STJ93786 200 µl
EUR 197
Description: Rabbit polyclonal to IkappaB-beta.

Anti-kappa-epsilon antibody

STJ93787 200 µl
EUR 197
Description: Rabbit polyclonal to IkappaB-epsilon.

Anti-NF kappa antibody

STJ94454 200 µl
EUR 197
Description: Rabbit polyclonal to NFRkappaB.

Anti-PP2 kappa antibody

STJ95197 200 µl
EUR 197
Description: Rabbit polyclonal to PP2Ckappa.

anti- immunoglobulin kappa antibody

FNab04295 100µg
EUR 548.75
Description: Antibody raised against immunoglobulin kappa

Anti-immunoglobulin kappa antibody

PAab04295 100 ug
EUR 386

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RD-GOAT-Hu-48Tests 48 Tests
EUR 563

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RD-GOAT-Hu-96Tests 96 Tests
EUR 783

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

DLR-GOAT-Hu-48T 48T
EUR 554
Description: A sandwich quantitative ELISA assay kit for detection of Human Ghrelin-O-Acyltransferase (GOAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

DLR-GOAT-Hu-96T 96T
EUR 725
Description: A sandwich quantitative ELISA assay kit for detection of Human Ghrelin-O-Acyltransferase (GOAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RDR-GOAT-Hu-48Tests 48 Tests
EUR 589

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RDR-GOAT-Hu-96Tests 96 Tests
EUR 820

Polyclonal Goat Anti-EPB41L2 / 4.1G (aa 593 to 604) Antibody

APG00100G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-EPB41L2 / 4.1G (aa 593 to 604) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-TUSC4 / NPRL2 (aa 140 to 151) Antibody

APG00353G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-TUSC4 / NPRL2 (aa 140 to 151) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-BDH2 / DHRS6 (aa 60 to 71) Antibody

AMM04910G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-BDH2 / DHRS6 (aa 60 to 71) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-C2GnT-M (aa 273 to 284) Antibody

APR16228G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-C2GnT-M (aa 273 to 284) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-C2GnT-M (aa 410 to 422) Antibody

APR16229G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-C2GnT-M (aa 410 to 422) . This antibody is tested and proven to work in the following applications:

OR Antibody

20-abx217389
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug

OR Antibody

44609-100ul 100ul
EUR 252

OR Antibody

44609-50ul 50ul
EUR 187

OR Antibody

DF10250 200ul
EUR 304
Description: OR Antibody detects endogenous levels of total OR.

OR Antibody

ABD10250 100 ug
EUR 438

Goat IgG Secondary antibody Clone: pAb to UltraPolymer Goat Anti-Human IgG (H&L) HRP

A1278-15 15 ml
EUR 322
Description: Goat IgG Secondary antibody Clone: pAb against UltraPolymer Goat Anti-Human IgG (H&L) HRPfor application in IHC.The immunogen is Human IgG (H&L).This antibody can be used for detection of the target molecule in samples from Human.

Goat IgG Secondary antibody Clone: pAb to UltraPolymer Goat Anti-Human IgG (H&L) HRP

A1278-5 5 ml
EUR 165
Description: Goat IgG Secondary antibody Clone: pAb against UltraPolymer Goat Anti-Human IgG (H&L) HRPfor application in IHC.The immunogen is Human IgG (H&L).This antibody can be used for detection of the target molecule in samples from Human.

Anti-Human kappa light chain antibody

STJ16100578 1 mL
EUR 290

Mouse Anti-Human Ig Kappa antibody

STJ99554-100l 100 µl
EUR 91
Description: Unconjugated Mouse monoclonal to Human Ig Kappa antibody

Mouse Anti-Human Ig Kappa antibody

STJ99554-1mL 1 mL
EUR 514
Description: Unconjugated Mouse monoclonal to Human Ig Kappa antibody

Kappa, Light Chain; Clone KLC264 (Ready-To-Use)

A00156-0002 2 ml
EUR 103

Kappa, Light Chain; Clone KLC264 (Ready-To-Use)

A00156-0007 7 ml
EUR 181

Kappa, Light Chain; Clone KLC264 (Ready-To-Use)

A00156-0025 25 ml
EUR 444

Nuclear Factor Related To Kappa B Binding Protein (NFRKB) Antibody

20-abx136034
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Nuclear Factor Related To Kappa B Binding Protein (NFRKB) Antibody

20-abx008933
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Nuclear Factor Related To Kappa B Binding Protein (NFRkB) Antibody

20-abx177837
  • EUR 1205.00
  • EUR 578.00
  • 1 mg
  • 200 ug

Nuclear Factor Related To Kappa B Binding Protein (NFRkB) Antibody

20-abx173863
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Nuclear Factor Related To Kappa B Binding Protein (NFRKB) Antibody

20-abx326280
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Goat F(Ab')2 Anti Human Kappa Light Chain Polyclonal Antibody,Biotin

CPBT-65575GA 0.5 mg
EUR 580

Goat F(Ab')2 Anti Human Kappa Light Chain Polyclonal Antibody,RPE

CPBT-65578GA 0.5 ml
EUR 580

Polyclonal Goat Anti-TEB4 / MARCH-VI (aa 701 to 712) Antibody

APG00328G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-TEB4 / MARCH-VI (aa 701 to 712) . This antibody is tested and proven to work in the following applications:

Anti-Kappa Light Chains antibody

STJ16100380 1 mL
EUR 494

Anti-Mouse-IgG2a Kappa antibody

STJ16100662 1 mL
EUR 1489

Anti-Mouse-IgG2a Kappa antibody

STJ16100663 1 mL
EUR 871

Anti-Kappa Light Chain antibody

STJ16100959 100 tests
EUR 524

Anti-Kappa Light Chain antibody

STJ16101014 100 µg
EUR 354

Anti-PPM1K/Pp2C Kappa Antibody

A04319-1 100ul
EUR 397
Description: Rabbit Polyclonal PPM1K/Pp2C Kappa Antibody. Validated in IHC, WB and tested in Human, Mouse.

Anti-Opioid Receptor κ Antibody

A02906 100ug
EUR 406
Description: Rabbit Polyclonal Opioid Receptor κ Antibody. Validated in ELISA, WB and tested in Human, Mouse, Rat.

Anti-N kappa-p105 antibody

STJ96474 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p65 antibody

STJ96703 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ96704 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ96793 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ98276 100 µl
EUR 234
Description: Mouse monoclonal to NFkappaB-p65.

Anti-NF-kappa p65 antibody

STJ98601 200 µl
EUR 197
Description: Rabbit polyclonal to NF-kappaB p65.

Anti-N kappa-p100 antibody

STJ94458 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p100.

Anti-N kappa-p100 antibody

STJ94459 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p100.

Anti-N kappa-p105 antibody

STJ94460 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94461 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94462 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94463 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94464 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p65 antibody

STJ94467 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94468 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94469 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94470 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94471 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94472 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94473 200 µl
EUR 197
Description: NFkappaB-p65 is a protein encoded by the RELA gene which is approximately 60,2 kDa. NFkappaB-p65 is localised to the nucleus and cytoplasm. It is involved in activated TLR4 signalling, toll-like receptor signalling pathways, cytosolic sensors of pathogen-associated DNA and immune response. NF-kappa-B is a transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NFkappaB-p65 is expressed in the nervous system, intestine, bone, lung and skin. Mutations in the RELA gene result in Ependymoma, Reticuloendotheliosis and Retinitis Pigmentosa-50. STJ94473 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of NFkappaB-p65 protein.

Anti-N kappa-p65 antibody

STJ94474 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94475 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94476 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94477 200 µl
EUR 197
Description: Rabbit polyclonal to NFkappaB-p65.

Myeloid/lymphoid or mixed-lineage leukemia translocated to 10 (MLLT10) polyclonal antibody

ABP-PAB-10850 100 ug Ask for price

Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) polyclonal antibody

ABP-PAB-10851 100 ug Ask for price

Myeloid/lymphoid or mixed-lineage leukemia translocated to 2 (MLLT2) polyclonal antibody

ABP-PAB-10852 100 ug Ask for price

Myeloid/lymphoid or mixed-lineage leukemia translocated to 3 (MLLT3) polyclonal antibody

ABP-PAB-10853 100 ug Ask for price
SD rats fed unusual eating regimen had been set as regular management teams. 20 rats, 20 within the simvastatin group and 20 within the simvastatin nanocarrier group. After 5 weeks of drug intervention, the rats had been sacrificed and the aorta was taken to find out the sleek muscle cell apoptosis charge. Research have proven that simvastatin nanocarriers can extra successfully scale back blood lipids in hyperlipidemia rats, enhance the speed of clean muscle cell apoptosis in hyperlipidemia rats, and delay the onset of atherosclerosis.

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