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Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells

Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells
Posted by Nicole

Since ZIKV was first detected at Uganda in 1947 and, severe outbreaks have globally occurred within the Yap Island, the French Polynesia and Brazil. Although the variety of an infection and unfold of ZIKV have sharply rise, the pathogenesis or replication mechanisms ZIKV haven’t been properly studied. Zika virus (ZIKV) is lately highlighted Flavivirus, a mosquito born rising virus inflicting microcephaly and the Guillain-Barre syndrome in fetuses and adults, respectively. ZIKV polyprotein consists of three structural proteins named C, prM and E and 7 nonstructural proteins named NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 in 11-kb single-stranded constructive sense RNA genome. The perform of particular person ZIKV genes on the host innate immune responses have been barely studied.

On this research, we investigated the modulations of the NF-κB promoter exercise associated by the MDA5/RIG-I signaling pathway. Within the outcomes, two nonstructural proteins, NS2A and NS4A, dramatically suppressed the NF-κB promoter exercise by inhibiting signaling elements on MDA5/RIG-I signaling pathway associated to activation of NF-κB. Apparently, NS2A suppressed all parts of MDA5/RIG-I signaling pathway, however NS4A inhibited most signaling molecules, besides IKKε and IRF3-5D. As well as, each NS2A and NS4A down-regulated MDA5 associated NF-κB promoter exercise in dose-dependent method. Taken collectively, our outcomes introduced that NS2A and NS4A critically antagonize MDA5/RIG-I-mediated NF-κB manufacturing and people proteins could appear to be managed in several mechanisms. This research might assist perceive the mechanisms how ZIKV controls innate immune responses and could also be supplied for improvement of ZIKV-specific medicines.

 

 

Cytochrome P450 1A2 overcomes nuclear issue kappa B-mediated sorafenib resistance in hepatocellular carcinoma

Sorafenib resistance has grow to be the primary impediment within the efficient therapy of superior hepatocellular carcinoma (HCC) sufferers. Activation of nuclear issue kappa B (NF-κB) is a newly recognized mechanism that contributes to desensitized sorafenib. Cytochrome P450 1A2 (CYP1A2) capabilities as a tumor suppressor in HCC and its expression is negatively related to NF-κB within the liver. This research aimed to check whether or not CYP1A2 might overcome sorafenib resistance. To analyze whether or not CYP1A2 and NF-κB p65 performed roles in sorafenib desensitization, we established sorafenib-resistant (SR) HCC cells.
SR cells decreased the expression of CYP1A2 together with the upregulation of NF-κB p65. CYP1A2 overexpression attenuated SR cell proliferation, elevated sorafenib sensitivity, and inhibited the NF-κB pathway, whereas CYP1A2 silence confirmed reverse results. Sorafenib, together with omeprazole, a CYP1A2 inducer, considerably hindered the expansion and invasion of SR cells in vitro in addition to decreased the tumor development in vivo. The mixture therapy markedly elevated CYP1A2 expression and inhibited the sorafenib-induced NF-κB signaling. As well as, the overexpression of NF-κB p65 stimulated the SR cell development and desensitized sorafenib in SR cells, the place CYP1A2 overexpression reversed the phenomenon. Lastly, nearly all of HCC tissue samples displayed decreased CYP1A2 however elevated NF-κB p65 protein expression. Collectively, CYP1A2 can sensitize SR cells to sorafenib by way of inhibiting NF-κB p65 axis. Omeprazole together with sorafenib exerts a synergistic impact in assuaging acquired sorafenib resistance.
 Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells
Zika Virus NS2A and NS4A Downregulate the Promoter Activity of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells

Nuclear issue erythroid 2-related issue 2 (Nrf2) as a possible therapeutic goal for vitiligo

Vitiligo is an autoimmune illness of the pores and skin which causes lack of melanocytes from the dermis. Not too long ago, it’s demonstrated that oxidative stress (OS) performs a big function within the immuno-pathogenesis of vitiligo. A serious mechanism within the mobile protection in opposition to OS is activation of the nuclear issue erythroid2-related issue (Nrf2)-Kelch-like ECH-associated protein 1(Keap1)-antioxidant responsive aspect (ARE) signaling pathway. Not too long ago it has been proven that vitiligo melanocytes have impaired Nrf2-ARE signaling. Plenty of medicine together with these often called Nrf2 activators and people identified to own results to activate Nrf2, have been utilized in treating vitiligo with sure therapeutic results.
Additionally, research have proven that quite a lot of compounds can shield melanocytes in opposition to OS by way of activating Nrf2. These compounds could also be thought of as candidates for creating new medicine for vitiligo sooner or later. Nrf2 might be thought of as a possible therapeutic goal for vitiligo. This text ready a simvastatin-NLCs for the therapy of arteriosclerotic occlusive illness of decrease limbs. Taking the scale distribution, polydispersity coefficient, encapsulation effectivity and drug loading of simvastatin-NLCs as analysis indicators, numerous prescription elements of simvastatin- NLCs had been investigated. The in vitro launch conduct and stability of simvastatin-NLCs had been additionally investigated. A hyperlipidemia rat mannequin was established utilizing high-fat diets.

Goat anti Human kappa chain

41R-1042 1 mg
EUR 391.2
Description: Goat anti Human kappa chain secondary antibody

Goat Anti-Mouse Kappa antibody (AU)

STJ99353-100l 100 µl
EUR 214.8
Description: AU conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (AU)

STJ99353-1mL 1 mL
EUR 1198.8
Description: AU conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (HRP)

STJ99503-100l 100 µl
EUR 214.8
Description: HRP conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (HRP)

STJ99503-1mL 1 mL
EUR 1198.8
Description: HRP conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (FITC)

STJ99453-100l 100 µl
EUR 214.8
Description: FITC conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (FITC)

STJ99453-1mL 1 mL
EUR 1198.8
Description: FITC conjugated Goat polyclonal to Mouse Kappa

Goat Anti Human Kappa Light Chain Polyclonal Antibody,HRP

CPBT-65573GH 1 ml
EUR 696

Goat Anti Human Kappa Light Chain Polyclonal Antibody,FITC

CPBT-65572GH 1 mg
EUR 696

Goat Anti-Mouse Kappa antibody (Biotin)

STJ99403-100l 100 µl
EUR 214.8
Description: Biotin conjugated Goat polyclonal to Mouse Kappa

Goat Anti-Mouse Kappa antibody (Biotin)

STJ99403-1mL 1 mL
EUR 1198.8
Description: Biotin conjugated Goat polyclonal to Mouse Kappa

Goat anti Human Kappa Chain (HRP)

43C-CB9126 1 mg
EUR 475.2
Description: Goat anti Human Kappa Chain secondary antibody (HRP)

Goat anti Human kappa chain (HRP)

43R-1260 500 ug
EUR 429.6
Description: Goat anti Human kappa chain secondary antibody (HRP)

Goat anti Human kappa chain (HRP)

43R-1266 500 ug
EUR 505.2
Description: Goat anti Human kappa chain secondary antibody (HRP)

Goat anti Human Kappa Chain (FITC)

43C-CB9122 1 mg
EUR 433.2
Description: Goat anti Human Kappa Chain secondary antibody (FITC)

Goat anti Human kappa chain (FITC)

43R-1259 500 ug
EUR 420
Description: Goat anti Human kappa chain secondary antibody (FITC)

Goat anti Human kappa chain (FITC)

43R-1265 500 ug
EUR 482.4
Description: Goat anti Human kappa chain secondary antibody (FITC)

Goat anti Human Kappa light chain

20-S2301G000-S4 10 ml
EUR 165.6
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2301G000-V0 10 ml
EUR 133.2
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2501G000-V0 10 ml
EUR 178.8
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa light chain

20-S2503GND1-D0 5 ml
EUR 230.4
Description: Goat anti Human Kappa light chain antibody

Goat anti Human Kappa Chain (biotin)

43C-CB9125 1 mg
EUR 460.8
Description: Goat anti Human Kappa Chain secondary antibody (biotin)

Goat anti Human kappa chain (biotin)

43R-1258 500 ug
EUR 447.6
Description: Goat anti Human kappa chain secondary antibody (biotin)

Goat anti Human kappa chain (biotin)

43R-1264 500 ug
EUR 528
Description: Goat anti Human kappa chain secondary antibody (biotin)

Goat anti Human Kappa Chain (rhodamine)

43C-CB9123 1 mg
EUR 433.2
Description: Goat anti Human Kappa Chain secondary antibody (Rhodamine)

Goat anti Human kappa chain (rhodamine)

43R-1261 500 ug
EUR 420
Description: Goat anti Human kappa chain secondary antibody (rhodamine)

Goat anti Human Kappa Chain (Fab'2)

41C-CJ0129 1 mg
EUR 406.8
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2)

Goat anti Human Kappa Chain (Alk Phos)

43C-CB9127 1 mg
EUR 500.4
Description: Goat anti Human Kappa Chain secondary antibody (Alk Phos)

Goat anti Human kappa chain (Alk Phos)

43R-1257 500 ug
EUR 482.4
Description: Goat anti Human kappa chain secondary antibody (Alk Phos)

Goat anti Human Kappa Chain (Texas Red)

43C-CB9124 1 mg
EUR 433.2
Description: Goat anti Human Kappa Chain secondary antibody

Goat anti Human Kappa + Lambda light chain

20-S1701G000-V0 10 ml
EUR 165.6
Description: Goat anti Human kappa + lambda light chain secondary antibody

Goat F(Ab')2 Anti Human Kappa Light Chain Polyclonal Antibody,RPE

CPBT-65578GA 0.5 ml
EUR 696

Goat anti Human Kappa Chain (Fab'2) (HRP)

43C-CJ0132 1 mg
EUR 546
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2) (HRP)

Goat anti Human Kappa Chain (Fab'2) (FITC)

43C-CJ0130 1 mg
EUR 462
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2) (FITC)

Goat F(Ab')2 Anti Human Kappa Light Chain Polyclonal Antibody,Biotin

CPBT-65575GA 0.5 mg
EUR 696

Goat anti Human Kappa Chain (Fab'2) (Texas Red)

43C-CJ0131 1 mg
EUR 466.8
Description: Goat anti Human Kappa Chain secondary antibody (Fab'2)

Goat Anti-Mouse Kappa-HRP

LF-SA8066H 1.0 ml Ask for price
Description: Goat polyclonal to Mouse Kappa

Goat anti Mouse Kappa Light Chain

70R-KG001 1 ml
EUR 289.2
Description: Affinity purified Goat anti Mouse Kappa Light Chain antibody

HRP*Polyclonal Goat Anti-Mouse Kappa

C030214-101ml 10.1ml
EUR 272.4

HRP*Polyclonal Goat Anti-Mouse Kappa

C030214-1ml 1ml
EUR 1134

FITC*Polyclonal Goat Anti-Mouse Kappa

C030614-101ml 10.1ml
EUR 272.4

FITC*Polyclonal Goat Anti-Mouse Kappa

C030614-1ml 1ml
EUR 1134

BIOTIN*Polyclonal Goat Anti-Mouse Kappa

C030814-101ml 10.1ml
EUR 272.4

BIOTIN*Polyclonal Goat Anti-Mouse Kappa

C030814-1ml 1ml
EUR 1134

Goat anti Mouse Kappa Light Chain (HRP)

60R-KG001hrp 1 ml
EUR 548.4
Description: Goat anti Mouse Kappa Light Chain secondary antibody (HRP)

Mouse anti Human Kappa Light Chain antibody

10-K100A 1 mg
EUR 392.4
Description: Mouse monoclonal Mouse anti Human Kappa Light Chain antibody

Mouse anti Human Kappa Light Chain antibody

10R-K100a 1 mg
EUR 586.8
Description: Mouse monoclonal Mouse anti Human Kappa Light Chain antibody

Anti-NF kappa antibody

STJ94454 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFRkappaB.

Anti-PP2 kappa antibody

STJ95197 200 µl
EUR 236.4
Description: Rabbit polyclonal to PP2Ckappa.

Anti-PP2C kappa Antibody

A04319 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for PP2C kappa Antibody (PPM1K) detection.tested for WB in Human.

Anti-Actin- kappa Antibody

A14672-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Actin- kappa Antibody (ACTBL2) detection. Tested with WB in Human, Mouse.

Anti-CCR4 (Mogamulizumab), Human IgG1, kappa Antibody

A2005-200 200 µg
EUR 818.4

Mouse Anti-Human Ig Kappa antibody

STJ99554-100l 100 µl
EUR 109.2
Description: Unconjugated Mouse monoclonal to Human Ig Kappa antibody

Mouse Anti-Human Ig Kappa antibody

STJ99554-1mL 1 mL
EUR 616.8
Description: Unconjugated Mouse monoclonal to Human Ig Kappa antibody

Sheep Anti Human Kappa Light Chain Polyclonal Antibody

CPBT-65568SH 1 ml
EUR 670.8

Mouse Anti Human Kappa Light Chain Monoclonal Antibody

CABT-48888MH 0.5 mg
EUR 795.6

Goat Anti-human Kappa light chain (bound and free)-HRP conjugate

MKUL11-HRP 0.5ml
EUR 255.6

anti- immunoglobulin kappa antibody

FNab04295 100µg
EUR 658.5
Description: Antibody raised against immunoglobulin kappa

Rabbit Anti Human Kappa Light Chain Polyclonal Antibody

CPBT-65570RH 6 ml
EUR 639.6

Anti-N kappa-p65 antibody

STJ96703 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ96704 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ96793 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ98276 100 µl
EUR 280.8
Description: Mouse monoclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94467 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94468 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94469 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94470 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94471 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94472 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94473 200 µl
EUR 236.4
Description: NFkappaB-p65 is a protein encoded by the RELA gene which is approximately 60,2 kDa. NFkappaB-p65 is localised to the nucleus and cytoplasm. It is involved in activated TLR4 signalling, toll-like receptor signalling pathways, cytosolic sensors of pathogen-associated DNA and immune response. NF-kappa-B is a transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NFkappaB-p65 is expressed in the nervous system, intestine, bone, lung and skin. Mutations in the RELA gene result in Ependymoma, Reticuloendotheliosis and Retinitis Pigmentosa-50. STJ94473 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of NFkappaB-p65 protein.

Anti-N kappa-p65 antibody

STJ94474 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94475 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94476 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-N kappa-p65 antibody

STJ94477 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p65.

Anti-immunoglobulin kappa antibody

PAab04295 100 ug
EUR 463.2

Anti-Human kappa light chain antibody

STJ16100578 1 mL
EUR 348

Anti-N kappa-p105 antibody

STJ96474 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p100 antibody

STJ94458 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p100.

Anti-N kappa-p100 antibody

STJ94459 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p100.

Anti-N kappa-p105 antibody

STJ94460 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94461 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94462 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94463 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-N kappa-p105 antibody

STJ94464 200 µl
EUR 236.4
Description: Rabbit polyclonal to NFkappaB-p105.

Anti-PPM1K/Pp2C Kappa Antibody

A04319-1 100ul
EUR 476.4
Description: Rabbit Polyclonal PPM1K/Pp2C Kappa Antibody. Validated in IHC, WB and tested in Human, Mouse.

Kappa Antibody

P1045-01m 0.1m
EUR 163.2

Kappa Antibody

P1045-1ml 1ml
EUR 337.2

Kappa Light Chain (Kappa-IgLC) Antibody

abx412052-1ml 1 ml
EUR 526.8

Kappa Light Chain (Kappa-IgLC) Antibody

abx411144-1mg 1 mg
EUR 661.2

Kappa Light Chain (Kappa-IgLC) Antibody

abx411421-1ml 1 ml
EUR 526.8

Kappa Light Chain (Kappa-IgLC) Antibody

abx411422-05mg 0.5 mg
EUR 794.4

Kappa Light Chain (Kappa-IgLC) Antibody

abx413125-1mg 1 mg
EUR 994.8

Kappa Light Chain (Kappa-IgLC) Antibody

abx415783-1mg 1 mg
EUR 526.8

Kappa Light Chain (Kappa-IgLC) Antibody

abx415786-05mg 0.5 mg
EUR 477.6

Kappa Light Chain (Kappa-IgLC) Antibody

abx415797-1mg 1 mg
EUR 594

Kappa Light Chain (Kappa-IgLC) Antibody

abx415799-05mg 0.5 mg
EUR 477.6

Mouse Anti-Human Ig Kappa antibody (AU)

STJ99385-100l 100 µl
EUR 97.2
Description: AU conjugated Mouse monoclonal to Human Ig Kappa

Mouse Anti-Human Ig Kappa antibody (AU)

STJ99385-1mL 1 mL
EUR 475.2
Description: AU conjugated Mouse monoclonal to Human Ig Kappa

Anti-Mouse-IgG2a Kappa antibody

STJ16100662 1 mL
EUR 1786.8

Anti-Mouse-IgG2a Kappa antibody

STJ16100663 1 mL
EUR 1045.2

Sheep Anti Human Kappa Light Chain Polyclonal Antibody,FITC

CPBT-65567SH 1 ml
EUR 696

Free Human Kappa Light Chain antibody

10-7812 1 mg
EUR 392.4
Description: Mouse monoclonal Human Free Kappa Light Chain antibody

Human Ig light chain kappa Antibody

20-abx134356
  • EUR 427.20
  • EUR 678.00
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

Mouse Anti-Human Ig Kappa antibody (HRP)

STJ99535-100l 100 µl
EUR 97.2
Description: HRP conjugated Mouse monoclonal to Human Ig Kappa

Mouse Anti-Human Ig Kappa antibody (HRP)

STJ99535-1mL 1 mL
EUR 475.2
Description: HRP conjugated Mouse monoclonal to Human Ig Kappa

Mouse Anti-Human Ig Kappa antibody (FITC)

STJ99485-100l 100 µl
EUR 97.2
Description: FITC conjugated Mouse monoclonal to Human Ig Kappa

Mouse Anti-Human Ig Kappa antibody (FITC)

STJ99485-1mL 1 mL
EUR 475.2
Description: FITC conjugated Mouse monoclonal to Human Ig Kappa

Anti-Opioid Receptor κ Antibody

A02906 100ug
EUR 487.2
Description: Rabbit Polyclonal Opioid Receptor κ Antibody. Validated in ELISA, WB and tested in Human, Mouse, Rat.

immunoglobulin Kappa (immunoglobulin kappa) Antibody

abx234295-100ug 100 ug
EUR 610.8

Mouse Anti-Human Ig Kappa antibody (Biotin)

STJ99435-100l 100 µl
EUR 97.2
Description: Biotin conjugated Mouse monoclonal to Human Ig Kappa

Mouse Anti-Human Ig Kappa antibody (Biotin)

STJ99435-1mL 1 mL
EUR 475.2
Description: Biotin conjugated Mouse monoclonal to Human Ig Kappa

Kappa Light Chain (Kappa-IgLC) Antibody (AP)

abx411146-1ml 1 ml
EUR 678

Kappa Light Chain (Kappa-IgLC) Antibody (AP)

abx411216-1ml 1 ml
EUR 678

Anti-N kappa-p105/p50 antibody

STJ98274 100 µl
EUR 280.8
Description: Mouse monoclonal to NFkappaB-p105/p50.

Anti-N kappa-p105/p50 antibody

STJ98275 100 µl
EUR 280.8
Description: Mouse monoclonal to NFkappaB-p105/p50.

Anti-N kappa-p105/p50 antibody

STJ94465 200 µl
EUR 236.4
Description: NFkappaB-p105/p50 is a protein encoded by the NFKB1 gene which is approximately 105,3 kDa. NFkappaB-p105/p50 is localised to the nucleus and cytoplasm. It is involved in activated TLR4 signalling, the TNFR1 pathway, toll-like receptor signalling pathways and 4-1BB pathway. It is a pleiotropic transcription factor that acts as the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. Dimers bind at kappa-B sites in the DNA of their target genes. Different dimer combinations act as transcriptional activators or repressors, respectively. NFkappaB-p105/p50 is expressed in the nervous system, liver, muscle, eye and lymph node. Mutations in the NFKB1 gene may result in common variable immunodeficiency and intestinal perforation. STJ94465 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of NFkappaB-p105/p50 protein.

Anti-N kappa-p105/p50 antibody

STJ94466 200 µl
EUR 236.4
Description: NFkappaB-p105/p50 is a protein encoded by the NFKB1 gene which is approximately 105,3 kDa. NFkappaB-p105/p50 is localised to the nucleus and cytoplasm. It is involved in activated TLR4 signalling, the TNFR1 pathway, toll-like receptor signalling pathways and 4-1BB pathway. It is a pleiotropic transcription factor that acts as the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. Dimers bind at kappa-B sites in the DNA of their target genes. Different dimer combinations act as transcriptional activators or repressors, respectively. NFkappaB-p105/p50 is expressed in the nervous system, liver, muscle, eye and lymph node. Mutations in the NFKB1 gene may result in common variable immunodeficiency and intestinal perforation. STJ94466 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of NFkappaB-p105/p50 protein.

Kappa Light Chain (Kappa-IgLC) Antibody (HRP)

abx411147-1ml 1 ml
EUR 594

Kappa Light Chain (Kappa-IgLC) Antibody (RPE)

abx411150-025mg 0.25 mg
EUR 760.8

Kappa Light Chain (Kappa-IgLC) Antibody (RPE)

abx411219-05mg 0.5 mg
EUR 910.8

Kappa Light Chain (Kappa-IgLC) Antibody (HRP)

abx413129-01mg 0.1 mg
EUR 594

Kappa Light Chain (Kappa-IgLC) Antibody (HRP)

abx415785-1ml 1 ml
EUR 594

Kappa Light Chain (Kappa-IgLC) Antibody (HRP)

abx415788-1ml 1 ml
EUR 594

Kappa Light Chain (Kappa-IgLC) Antibody (RPE)

abx415789-05ml 0.5 ml
EUR 760.8

Kappa Light Chain (Kappa-IgLC) Antibody (HRP)

abx414986-05mg 0.5 mg
EUR 861.6

Kappa Light Chain (Kappa-IgLC) Antibody (HRP)

abx412923-05mg 0.5 mg
EUR 861.6

Mouse anti Human IgG Kappa

40R-1013 500 ug
EUR 678
Description: Mouse anti Human IgG Kappa Light Chain secondary antibody

Kappa Light Chain (Kappa-IgLC) Antibody (FITC)

abx411143-05mg 0.5 mg
EUR 526.8

Kappa Light Chain (Kappa-IgLC) Antibody (FITC)

abx415784-1mg 1 mg
EUR 560.4

Anti-EGFR domain III (Nimotuzumab), Human IgG1, kappa Antibody

A2004-200 200 µg
EUR 612

Kappa Light Chain (Kappa-IgLC) Antibody (TRITC)

abx411145-05mg 0.5 mg
EUR 744

Anti-mouse Ig kappa chain antibody

STJ15100201 250 µg
EUR 348
Description: This monoclonal antibody enables sensitive and specific detection of mouse Ig in e.g. antigen-specific ELISA and for enumeration of antigen-specific Ig producing cells using ELISpot.

Anti-mouse Ig kappa chain antibody

STJ15100202 250 µg
EUR 391.2
Description: This monoclonal antibody enables sensitive and specific detection of mouse Ig in e.g. antigen-specific ELISA and for enumeration of antigen-specific Ig producing cells using ELISpot.

Kappa Light Chain (Kappa-IgLC) Antibody (Biotin)

abx411149-1mg 1 mg
EUR 727.2

Kappa Light Chain (Kappa-IgLC) Antibody (Biotin)

abx411218-1mg 1 mg
EUR 594

Kappa Light Chain (Kappa-IgLC) Antibody (Biotin)

abx415787-05mg 0.5 mg
EUR 560.4

KAPPA Antibody (PE)

abx200537-100tests 100 tests
EUR 1011.6

KAPPA Antibody (PE)

abx200539-100tests 100 tests
EUR 727.2

Anti-mouse Ig kappa lambda antibody

STJ15100203 250 µg
EUR 348
Description: These monoclonal antibodies enablel sensitive and specific detection of mouse immunoglobulin lambda light chains in e.g. ELISA and for enumeration of Ig producing cells using ELISpot.

KAPPA Antibody (APC)

abx201104-100tests 100 tests
EUR 777.6

DGK kappa Antibody

20-abx133186
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

PTP kappa antibody

70R-50295 100 ul
EUR 292.8
Description: Purified Polyclonal PTP kappa antibody

PTP kappa Antibody

20-abx008797
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul
SD rats fed unusual eating regimen had been set as regular management teams. 20 rats, 20 within the simvastatin group and 20 within the simvastatin nanocarrier group. After 5 weeks of drug intervention, the rats had been sacrificed and the aorta was taken to find out the sleek muscle cell apoptosis charge. Research have proven that simvastatin nanocarriers can extra successfully scale back blood lipids in hyperlipidemia rats, enhance the speed of clean muscle cell apoptosis in hyperlipidemia rats, and delay the onset of atherosclerosis.

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