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Protective Effect of NADPH Oxidase Nuclear factor 

nfkb-p65
Posted by Nicole

Protecting impact of resveratrol on estrogen deficiency-induced osteoporosis although attenuating NADPH oxidase 4/nuclear issue kappa B pathway by growing miR-92b-3p expression

 

Introduction: Resveratrol (RES) reveals estrogen-like results and has potential functions to therapy of osteoporosis attributable to estrogen deficiency; nonetheless, the precise mechanism of motion of RES stays unclear. Right here, we examined the therapeutic results of RES on ovariectomized (OVX) rats with osteoporosis and decided the underlying mechanism.
Strategies: We established an OVX rat mannequin to check osteoporosis attributable to estrogen deficiency. The therapy teams got orally with RES (50, 100, and 200 mg/day), the estrogen group acquired 0.Eight mg/kg E2 every day through oral route, and the sham-operated and management teams acquired an equal dose of sodium carboxymethylcellulose orally. After 12 weeks of therapy, we used real-time quantitative polymerase chain response (PCR) and Western blot evaluation to measure the gene and protein expression of miR-92b-3p, Nox4, NF-κBp65, IκB, BMP2, Smad7, and RUNX-2 in bone tissues.

Cytochrome P450 4A11 (CYP4A11) Antibody

Proper femur structural parameters had been evaluated by micro-CT. Twin-energy X-ray 4500 W was used to find out systemic bone mineral density (BMD). Enzyme-linked immunosorbent assay (ELISA) kits had been used to find out the serum ranges of bone alkaline phosphatase (BALP), osteoprotegerin (OPG), anti-tartrate acid phosphatase-5b (PTRA5b), and carboxylated terminal peptide (CTX-I). The rat femoral bone specimens had been stained utilizing hematoxylin and eosin for pathological examination.
nfkb-p65
nfkb-p65
Outcomes: We noticed elevated ranges of serum estrogen in each ovaries, elevated miR-92b-3p ranges in bone tissues, lowered ranges of Nox4, NF-κBp65, p-IκB-a, and cathepsin Ok, and elevated gene and protein expression of BMP2, Smad7, and RUNX-2 within the OVX rat mannequin of osteoporosis after therapy with RES.
Elevated ranges of BALP, OPG, ALP, and BMD together with lowered ranges of TRAP-5b and CTX-I had been additionally noticed. The structural mannequin index (SMI) and the trabecular area (Tb. Sp) decreased, whereas the trabecular thickness (Tb. Th), bone quantity fraction (BV/TV), trabecular quantity (Tb.N), and tissue bone density (Conn.D) elevated, thereby bettering osteoporosis induced by estrogen deficiency in each ovaries.
Conclusion: Cathepsin Ok expression and Nox4/NF-κB signaling pathway had been suppressed by the elevated expression of miR-92b-3p. This inhibition was pivotal within the protecting impact of RES towards osteoporosis induced by estrogen deficiency in each ovaries. Thus, RES effectively alleviated osteoporosis induced by estrogen deficiency in rats.
Key phrases: NF-κBp65; Nox4; miR-92b-3p; osteoporosis; resveratrol.

 

 

 

Efficacy of inexperienced tea, its polyphenols and nanoformulation in experimental colitis and the function of non-canonical and canonical nuclear issue kappa beta (NF-kB) pathway: a preclinical in-vivo and in-silico exploratory examine

NF-kB performs a serious function within the aetiopathogenesis of inflammatory-colitis. On this examine, we evaluated the efficacy of inexperienced tea and its polyphenols and their nanoformulation in Tri-Nitro Benzene Sulfonic acid (TNBS) induced colitis in in-vivo system (Rat) and the involvement of non-canonical and canonical NF-kB pathway in inexperienced tea mediated safety (in-silico platform).

We used the Wister rat mannequin of TNBS-induced colitis. Rats had been grouped into eleven teams (six animals every) and administered car (ethanol), TNBS, Epicatechin (EC), Epigallocatechin (EGC), Epicatechin-gallate (ECG), Epigallocatechin-gallate (EGCG), sulfasalazine, inexperienced tea, EGCG + sulfasalazine, nano-EGCG and nano-EGCG + sulfasalazine for 14 days after induction of colitis.

Cytochrome P450 4A11 / 22 Blocking Peptide

Colonic tissue was evaluated for the extent of malondialdehyde, myeloperoxidase exercise, catalase, lowered glutathione, glutathione peroxidase, IL-6, TNF-α, IL-1β, NF-κB and morphological and histopathological proof of harm. Within the in-silico half, molecular docking and dynamic simulation examine of EGCG was accomplished towards totally different targets in NF-kB for detailed analysis of the function of non-canonical and canonical NF-KB pathway.

In our examine, EGCG lowered colonic irritation, markers of oxidative stress, TNF-α, NF-κB, IL-1β and IL-6. Nano-EGCG + sulfasalazine was extra efficacious when in comparison with EGCG + sulfasalazine. In molecular docking and molecular dynamic simulation research, EGCG confirmed a superb binding profile to the inhibitor binding websites of IKK-beta, IKK-alpha and NIK. Thus, it may be concluded that EGCG confirmed protecting motion in experimental colitis appearing by each non-canonical and canonical NF-kB pathway.

Nano-EGCG + sulfasalazine mixture confirmed higher safety than nano-EGCG alone. Communicated by Ramaswamy H. Sarma.

 

Monoclonal MOAP1 Antibody (monoclonal) (M01), Clone: 4A11

AMM03806G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human MOAP1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4A11. This antibody is applicable in WB, E

Monoclonal PARVB Antibody (monoclonal) (M01), Clone: 4A11

APR17756G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human PARVB (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4A11. This antibody is applicable in WB, E

Monoclonal THUMPD1 Antibody (monoclonal) (M01), Clone: 4A11

AMM04196G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human THUMPD1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4A11. This antibody is applicable in WB and IHC, E

CD4 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA500479 100 µl Ask for price

CD4 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA500479S 30 µl Ask for price

PGR mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA805565 100 µl Ask for price

PGR mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA805565S 30 µl Ask for price

MPI mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA504771 100 µl Ask for price

MPI mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA504771S 30 µl Ask for price

MMP2 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA806846 100 µl Ask for price

MMP2 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA806846S 30 µl Ask for price

APOH mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA807147 100 µl Ask for price

APOH mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA807147S 30 µl Ask for price

DGKA mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA504047 100 µl Ask for price

DGKA mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA504047S 30 µl Ask for price

SLA2 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA505142 100 µl Ask for price

SLA2 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA505142S 30 µl Ask for price

CHAC1 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA507049 100 µl Ask for price

CHAC1 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA507049S 30 µl Ask for price

RBPMS mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA800215 100 µl Ask for price

RBPMS mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA800215S 30 µl Ask for price

TMPRSS5 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA503409 100 µl Ask for price

TMPRSS5 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA503409S 30 µl Ask for price

TSC22D1 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA505061 100 µl Ask for price

TSC22D1 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA505061S 30 µl Ask for price

Mouse monoclonal Anti-Cytochrome P450 4A11 Clone M25-P2A10

TA353137L 500 µg Ask for price

Anti-SSX2 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA500618 100 µl Ask for price

Anti-SSX2 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

TA500618S 30 µl Ask for price

Human IgG (F(ab)2 specific) mouse monoclonal antibody, clone 4A11, PE

SM3062RP 100 µg Ask for price

Human IgG (F(ab)2 specific) mouse monoclonal antibody, clone 4A11, Purified

SM3062P 100 µg Ask for price

Carrier-free (BSA/glycerol-free) DGKA mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF504047 100 µg Ask for price

Carrier-free (BSA/glycerol-free) CD4 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF500479 100 µg Ask for price

Carrier-free (BSA/glycerol-free) SSX2 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF500618 100 µg Ask for price

Carrier-free (BSA/glycerol-free) PGR mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF805565 100 µg Ask for price

Carrier-free (BSA/glycerol-free) MMP2 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF806846 100 µg Ask for price

Carrier-free (BSA/glycerol-free) APOH mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF807147 100 µg Ask for price

Carrier-free (BSA/glycerol-free) SLA2 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF505142 100 µg Ask for price

Carrier-free (BSA/glycerol-free) MPI mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF504771 100 µg Ask for price

Carrier-free (BSA/glycerol-free) CHAC1 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF507049 100 µg Ask for price

Carrier-free (BSA/glycerol-free) RBPMS mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF800215 100 µg Ask for price

Carrier-free (BSA/glycerol-free) TMPRSS5 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF503409 100 µg Ask for price

Carrier-free (BSA/glycerol-free) TSC22D1 mouse monoclonal antibody, clone OTI4A11 (formerly 4A11)

CF505061 100 µg Ask for price

Anti-LHX4 (4A11)

YF-MA19614 100 ug
EUR 435.6
Description: Mouse monoclonal to LHX4

Anti-MAP1 (4A11)

YF-MA19202 100 ug
EUR 435.6
Description: Mouse monoclonal to MAP1

Anti-SSX3 (4A11)

YF-MA17194 100 ug
EUR 435.6
Description: Mouse monoclonal to SSX3

Anti-JNK1 (4A11)

YF-MA14911 100 ug
EUR 435.6
Description: Mouse monoclonal to JNK1

anti-PDK1 (4A11)

LF-MA30516 100 ul
EUR 632.4
Description: Mouse Monoclonal to PDK1

anti-DLL4 (4A11)

LF-MA30736 100 ul
EUR 632.4
Description: Mouse Monoclonal to DLL4

anti-DLL4 (4A11)

LF-MA30749 100 ul
EUR 632.4
Description: Mouse Monoclonal to DLL4

Anti-CaMKK (4A11)

YF-MA19533 100 ug
EUR 435.6
Description: Mouse monoclonal to CaMKK

Anti-FOXK2 (4A11)

YF-MA20345 100 ug
EUR 435.6
Description: Mouse monoclonal to FOXK2

Anti-PARVB (4A11)

YF-MA11471 100 ug
EUR 435.6
Description: Mouse monoclonal to PARVB

Anti-CRLF2 (4A11)

YF-MA11626 100 ug
EUR 435.6
Description: Mouse monoclonal to CRLF2

Anti-APRIL (4A11)

YF-MA16500 100 ug
EUR 435.6
Description: Mouse monoclonal to APRIL

Anti-CNKSR3 (4A11)

YF-MA19966 100 ug
EUR 435.6
Description: Mouse monoclonal to CNKSR3

Anti-THUMPD1 (4A11)

YF-MA11563 100 ug
EUR 435.6
Description: Mouse monoclonal to THUMPD1

TIGIT Antibody [4A11]

RF16055-002mg 0.02 mg
EUR 229.7
Description: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

TIGIT Antibody [4A11]

RF16055-01mg 0.1 mg
EUR 594.26
Description: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

TIGIT Antibody [4A11]

MBS154592-01mg 0.1mg
EUR 500

TIGIT Antibody [4A11]

MBS154592-5x01mg 5x0.1mg
EUR 2230

Anti-Hey L (4A11)

YF-MA18109 100 ug
EUR 435.6
Description: Mouse monoclonal to Hey L

Anti-Claudin 4 (4A11)

YF-MA12513 100 ug
EUR 435.6
Description: Mouse monoclonal to Claudin 4

Copa antibody | AB01/4A11

MBS226300-01mL 0.1mL
EUR 485

Copa antibody | AB01/4A11

MBS226300-5x01mL 5x0.1mL
EUR 2015

Monoclonal IkBalpha Antibody (Clone 6A055), Clone: 6A055

AMM00004G 0.1mg
EUR 633.6
Description: A Monoclonal antibody against Human IkBalpha (Clone 6A055). The antibodies are raised in Mouse and are from clone 6A055. This antibody is applicable in WB and IHC, IP

Monoclonal TNFRSF10A / DR4 Antibody (clone 32A1380), Clone: 32A1380

AMM01748G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human TNFRSF10A / DR4 (clone 32A1380). The antibodies are raised in Mouse and are from clone 32A1380. This antibody is applicable in WB and IHC-P, Neut, Flo

Monoclonal Glutathione Peroxidase 1 Antibody (Clone 2A10), Clone: Clone 2A10

AMRa00026G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human Glutathione Peroxidase 1 (Clone 2A10). The antibodies are raised in Mouse and are from clone Clone 2A10. This antibody is applicable in IP

Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation by Nuclear Issue Erythroid 2-Associated Issue 2 Activation

 

 

NFKB1

MBS8535435-01mLAF405S 0.1mL(AF405S)
EUR 565

NFKB1

MBS8535435-01mLAF610 0.1mL(AF610)
EUR 565

NFKB1

MBS8535435-01mLAF635 0.1mL(AF635)
EUR 565

NFKB1

MBS8536039-01mL 0.1mL
EUR 325

NFKB1

MBS8536039-01mLAF405L 0.1mL(AF405L)
EUR 565

NFKB1

MBS8536039-01mLAF405S 0.1mL(AF405S)
EUR 565

NFKB1

MBS8536039-01mLAF610 0.1mL(AF610)
EUR 565

NFKB1

MBS8536039-01mLAF635 0.1mL(AF635)
EUR 565

NFKB1 siRNA

20-abx925825
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  • 15 nmol
  • 30 nmol

NFKB1 siRNA

20-abx925826
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  • 15 nmol
  • 30 nmol

Kappa (NFKB1)

MO47031 100 ul
EUR 418.8

Kappa (NFKB1)

MBS556130-01mL 0.1mL
EUR 455

Kappa (NFKB1)

MBS556130-5x01mL 5x0.1mL
EUR 1895

NFKB1 Peptide

MBS3229034-01mg 0.1mg
EUR 180

NFKB1 Peptide

MBS3229034-5x01mg 5x0.1mg
EUR 730

NFKB1 antibody

10R-11003 100 ug
EUR 344
Description: Mouse monoclonal NFKB1 antibody

NFKB1 antibody

10R-11155 100 ug
EUR 344
Description: Mouse Monoclonal NFKB1 antibody

NFKB1 antibody

20-PR03 100 ul Ask for price
Description: Rabbit polyclonal NFKB1 antibody

NFKB1 Antibody

35588 100ul
EUR 319

NFKB1 Antibody

35588-100ul 100ul
EUR 302.4

NFKB1 antibody

39087 100ul
EUR 439

NFKB1 antibody

39087-100ul 100ul
EUR 302.4

NFKB1 Antibody

E035588 100μg/100μl
EUR 255
Description: Available in various conjugation types.

NFKB1 Antibody

E10-30224 100μg/100μl
EUR 225
Description: Available in various conjugation types.

NFKB1 Antibody

E10-30234 100μg/100μl
EUR 225
Description: Available in various conjugation types.

NFKB1 Antibody

1-CSB-PA020085
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  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

NFKB1 Antibody

1-CSB-PA020086
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/5000

NFKB1 Antibody

1-CSB-PA020090
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

NFKB1 Antibody

1-CSB-PA020096
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

NFKB1 Antibody

1-CSB-PA015759GA01HU
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  • 150ul
  • 50ul
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

NFKB1 antibody

E39-05702 100ug/100ul
EUR 225
Description: Available in various conjugation types.

NFKB1 antibody

E39-05703 100ug/100ul
EUR 225
Description: Available in various conjugation types.

NFKB1 antibody

E39-10334 100ug/100ul
EUR 225
Description: Available in various conjugation types.

NFKB1 Antibody

E911160 100ul
EUR 255
Description: Available in various conjugation types.

NFKB1 Antibody

E96667 100ul
EUR 255
Description: Available in various conjugation types.

NFKB1 Antibody

E300225 200ul
EUR 275
Description: Available in various conjugation types.

NFKB1 Antibody

BF0466-100ul 100ul
EUR 350

NFKB1 Antibody

BF0466-200ul 200ul
EUR 450

NFKB1 Antibody

BF0466-50ul 50ul
EUR 250

NFKB1 antibody

70R-15433 100 ug
EUR 302
Description: Rabbit polyclonal NFKB1 antibody

NFKB1 antibody

70R-10525 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal NFKB1 antibody

NFKB1 antibody

70R-18860 50 ul
EUR 289
Description: Rabbit polyclonal NFKB1 antibody

NFKB1 Antibody

1-CSB-PA004763
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

NFKB1 Antibody

1-CSB-PA003430
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/10000

NFKB1 Antibody

1-CSB-PA003431
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000

NFKB1 Antibody

1-CSB-PA003434
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000

NFKB1 Antibody

1-CSB-PA259078
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  • 100ul
  • 50ul
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:500-1:5000, IHC:1:5-1:20

NFKB1 Antibody

1-CSB-PA10354A0Rb
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF, ChIP; Recommended dilution: WB:1:500-1:5000, IHC:1:100-1:500, IF:1:50-1:500

NFKB1 Antibody

1-CSB-PA441503
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  • 100ul
  • 50ul
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:2000, WB:1:200-1:1000

NFKB1 Antibody

1-CSB-PA546304
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  • 100ul
  • 50ul
Description: A polyclonal antibody against NFKB1. Recognizes NFKB1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:500-1:5000, IHC:1:25-1:100

NFKB1 Antibody

F47079-0.4ML 0.4 ml
EUR 322.15
Description: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.

NFKB1 Antibody

F54028-0.1ML 0.1 ml
EUR 322.15
Description: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. [UniProt]

NFKB1 Antibody

F52441-0.4ML 0.4 ml
EUR 330.65
Description: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NFkB is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NFkB complexes are held in the cytoplasm in an inactive state complexed with members of the NFkB inhibitor (I-kappa-B) family. In a conventional activation pathway, IkB is phosphorylated by IkB kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NFkB complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NFkB p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NFkB proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

NFKB1 Antibody

GWB-MX421G 50ug Ask for price

NFKB1 Antibody

GWB-DB75B4 0.05 mg Ask for price

NFKB1 Antibody

R20321-0.1ML 100ul
EUR 347.65
Description: This antibody reacts to human nuclear factor-kappa-B p105 subunit and p50 subunit.

NFKB1 Antibody

R31224 100 ug
EUR 356.15
Description: Nuclear factor NF-kappa-B p105/p50, also called EBP-1 is a protein that in humans is encoded by the NFKB1 gene. By fluorescence in situ hybridization, the gene was assigned to human chromosome 4q24. NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing.

NFKB1 antibody

BF0466 100ug
EUR 355

NFKB1 Antibody

MBS7119961-005mg 0.05mg
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NFKB1 Antibody

MBS7119961-01mg 0.1mg
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NFKB1 Antibody

MBS7119961-5x01mg 5x0.1mg
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NFKB1 Antibody

MBS7119962-005mg 0.05mg
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NFKB1 Antibody

MBS7119962-01mg 0.1mg
EUR 190

NFKB1 Antibody

MBS7119962-5x01mg 5x0.1mg
EUR 845

NFKB1 Antibody

MBS7119963-005mg 0.05mg
EUR 150

NFKB1 Antibody

MBS7119963-01mg 0.1mg
EUR 190

NFKB1 Antibody

MBS7119963-5x01mg 5x0.1mg
EUR 845

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