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Estrogen Receptors Take part in silibinin-caused nuclear translocation of apoptosis-inducing issue in human breast most cancers MCF-7 cells
Our earlier research confirmed that silibinin promoted activation of caspases to induce apoptosis in human breast most cancers MCF-7 cells by down-regulating the protein expression stage of estrogen receptor (ER) α and up-regulating ERβ. Just lately, it has been reported that silibinin-induced apoptosis additionally concerned nuclear translocation of apoptosis-inducing issue (AIF).
Right here we report that silibinin induces nuclear translocation of AIF via the down-regulation of ERα and up-regulation of ERβ in a focus dependent method in MCF-7 cells.
AIF knockdown with siRNA considerably reverses silibinin-induced apoptosis. The nuclear translocation of AIF is enhanced by remedy with MPP, an ERα antagonist, and blocked with PPT, an ERα agonist. In distinction to ERα exercise, the nuclear AIF is elevated with an ERβ agonist, DPN and blocked with an ERβ antagonist, PHTPP.
Cytochrome P450 4A11 (CYP4A11) Antibody |
Autophagy, negatively regulated by ERα, positively controls AIF-mediated apoptosis, as evidenced by the preventive impact of autophagy inhibitor 3-MA and siRNA concentrating on LC3, on the nuclear translocation of AIF and cell demise induced by silibinin co-treatment with or with out MPP.
In sum we conclude that AIF in nuclei is concerned in silibinin-induced apoptosis, and the nuclear translocation of AIF is elevated by down-regulated ERα pathway and/or up-regulated ERβ pathway in MCF-7 cells, accompanying up-regulation of autophagy.
GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in Hepatocyte Nuclear Issue 1-Alpha Mutation Carriers
Sulfonylureas (SUs) present an efficacious first-line remedy in sufferers with hepatocyte nuclear issue 1-alpha (HNF1A)-diabetes, however SUs have limitations because of danger of hypoglycemia. Remedy based mostly on the incretin hormones, glucose-dependent insulinotropic peptide (GIP) and glucagon-like-peptide 1 (GLP-1), are characterised by their glucose-dependent insulinotropic actions with out danger of hypoglycemia.
The impact of SUs along with GIP or GLP-1, respectively, on insulin and glucagon secretion in sufferers with HNF1A-diabetes is presently unknown. To research this, ten HNF1A mutation carriers and ten non-diabetic controls had been recruited for a double-blinded, placebo-controlled, crossover examine together with six experimental days in a randomized order involving 2h euglycemic-hyperglycemic clamps with co-administration of 1) SU (glimepiride 1 mg) or placebo, mixed with 2) infusions of both GIP (1.5 pmol/kg/min), GLP-1 (0.5 pmol/kg/min) or saline (NaCl).
Cytochrome P450 4A11 / 22 Blocking Peptide |
In HNF1A mutation carriers we noticed: 1) hypoinsulinemia, 2) insulinotropic results of each GIP and GLP-1, 3) additive to supra-additive results on insulin secretion when combining SU+GIP and SU+GLP1, respectively, and 4) elevated fasting and arginine-induced glucagon ranges in comparison with non-diabetic controls.
Our examine suggests {that a} mixture of SU and incretin-based remedy could also be efficacious in sufferers with HNF1A-diabetes by way of potentiation of glucose-stimulated insulin secretion.
Monoclonal CRLF2 Antibody (monoclonal) (M03), Clone: 4A11 |
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| AMM03416G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A Monoclonal antibody against Human CRLF2 (monoclonal) (M03). The antibodies are raised in mouse and are from clone 4A11. This antibody is applicable in WB, E |
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Monoclonal PARVB Antibody (monoclonal) (M01), Clone: 4A11 |
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| APR17756G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A Monoclonal antibody against Human PARVB (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4A11. This antibody is applicable in WB, E |
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anti-PDK1 (4A11) |
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| LF-MA30516 | Abfrontier | 100 ul | EUR 632.4 |
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Description: Mouse Monoclonal to PDK1 |
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anti-DLL4 (4A11) |
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| LF-MA30736 | Abfrontier | 100 ul | EUR 632.4 |
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Description: Mouse Monoclonal to DLL4 |
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anti-DLL4 (4A11) |
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| LF-MA30749 | Abfrontier | 100 ul | EUR 632.4 |
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Description: Mouse Monoclonal to DLL4 |
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TIGIT Antibody [4A11] |
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| RF16055-002mg | ProSci | 0.02 mg | EUR 229.7 |
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Description: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2). |
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TIGIT Antibody [4A11] |
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| RF16055-01mg | ProSci | 0.1 mg | EUR 594.26 |
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Description: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2). |
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Anti-APRIL (4A11) |
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| YF-MA16500 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to APRIL |
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Anti-SSX3 (4A11) |
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| YF-MA17194 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to SSX3 |
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Anti-MAP1 (4A11) |
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| YF-MA19202 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to MAP1 |
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Anti-CaMKK (4A11) |
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| YF-MA19533 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to CaMKK |
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Anti-LHX4 (4A11) |
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| YF-MA19614 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to LHX4 |
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Anti-CNKSR3 (4A11) |
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| YF-MA19966 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to CNKSR3 |
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Anti-FOXK2 (4A11) |
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| YF-MA20345 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to FOXK2 |
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Anti-JNK1 (4A11) |
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| YF-MA14911 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to JNK1 |
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Anti-PARVB (4A11) |
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| YF-MA11471 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to PARVB |
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Anti-THUMPD1 (4A11) |
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| YF-MA11563 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to THUMPD1 |
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Anti-CRLF2 (4A11) |
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| YF-MA11626 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to CRLF2 |
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Anti-ASFV P72 Antibody | MASF-5A-Clone #10E11 |
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| MASF-5A-Clone-10E11 | Immunology Consultants Laboratory | 1 mg | EUR 667 |
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Description: Anti-ASFV P72 Antibody | MASF-5A-Clone #10E11 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Anti-ASFV P72 Antibody | MASF-5A-Clone #10G5 |
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| MASF-5A-Clone-10G5 | Immunology Consultants Laboratory | 1 mg | EUR 667 |
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Description: Anti-ASFV P72 Antibody | MASF-5A-Clone #10G5 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#3B11 |
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| MALV-30A-Clone-3B11 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
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Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#3B11 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#5A4 |
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| MALV-30A-Clone-5A4 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
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Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#5A4 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6C2 |
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| MALV-30A-Clone-6C2 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
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Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6C2 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6D7 |
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| MALV-30A-Clone-6D7 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
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Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6D7 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Cytochrome P450 4A11 antibody |
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| 70R-12729 | Fitzgerald | 100 ul | EUR 548.4 |
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Description: Affinity purified Rabbit polyclonal Cytochrome P450 4A11 antibody |
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Cytochrome P450 4A11 antibody |
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| 22646-100ul | SAB | 100ul | EUR 468 |
Anti-Hey L (4A11) |
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| YF-MA18109 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to Hey L |
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Anti-Claudin 4 (4A11) |
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| YF-MA12513 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to Claudin 4 |
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Cytochrome P450 4A11/22 antibody |
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| 70R-49642 | Fitzgerald | 100 ul | EUR 292.8 |
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Description: Purified Polyclonal Cytochrome P450 4A11/22 antibody |
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Cytochrome P450 4A11/22 Antibody |
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| 35260-100ul | SAB | 100ul | EUR 302.4 |
Cytochrome P450 4A11/22 Antibody |
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| 35260-50ul | SAB | 50ul | EUR 224.4 |
Cytochrome P450 4A11 (CYP4A11) Antibody |
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| 20-abx006298 | Abbexa |
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Cytochrome P450 4A11 / 22 Antibody |
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| 20-abx009352 | Abbexa |
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Cytochrome P450 4A11 (CYP4A11) Antibody |
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| 20-abx111934 | Abbexa |
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Cytochrome P450 4A11 / 22 Antibody |
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| 20-abx015130 | Abbexa |
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Cytochrome P450 4A11 (CYP4A11) Antibody |
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| abx033743-400ul | Abbexa | 400 ul | EUR 627.6 |
Cytochrome P450 4A11 (CYP4A11) Antibody |
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| abx033743-80l | Abbexa | 80 µl | EUR 343.2 |
Cytochrome P450 4A11/22 Antibody |
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| ABD13062 | Lifescience Market | 100 ug | EUR 525.6 |
Cytochrome P450 4A11/22 Antibody |
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| ABD4749 | Lifescience Market | 100 ug | EUR 525.6 |
Cytochrome P450 4A11 (CYP4A11) Antibody |
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| 20-abx320269 | Abbexa |
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Cytochrome P450 4A11 (CYP4A11) Antibody |
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| 20-abx339223 | Abbexa |
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Cytochrome P450 4A11 (CYP4A11) Antibody |
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| abx232168-100ug | Abbexa | 100 ug | EUR 610.8 |
Cytochrome P450 4A11 (CYP4A11) Antibody |
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| 20-abx213072 | Abbexa |
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Cytochrome P450 4A11/22 Antibody |
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| DF4749 | Affbiotech | 200ul | EUR 420 |
Anti-Cyclin A1 (4A11-5B5) |
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| YF-MA16598 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to Cyclin A1 |
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Anti-Musashi 1 / Msi1 (4A11) |
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| YF-MA10581 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to Musashi 1 / Msi1 |
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Anti-NFkB p105 / p50 (4A11) |
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| YF-MA10626 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to NFkB p105 / p50 |
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Anti-Cytochrome P450 4A11/22 Antibody |
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| A03493 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal Cytochrome P450 4A11/22 Antibody. Validated in WB and tested in Human. |
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Cytochrome P450 4A11 / 22 Blocking Peptide |
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| 20-abx062517 | Abbexa |
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Cytochrome P450 4A11/22 Blocking Peptide |
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| DF4749-BP | Affbiotech | 1mg | EUR 234 |
Cytochrome P450 4A11/22 Conjugated Antibody |
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| C35260 | SAB | 100ul | EUR 476.4 |
Human Cytochrome P450 4A11 (CYP4A11) ELISA Kit |
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| abx386773-96tests | Abbexa | 96 tests | EUR 1093.2 |
Goat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E06C2253-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Goat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E06C2253-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Goat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E06C2253-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Goat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E04C2253-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E04C2253-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E04C2253-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E03C2253-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E03C2253-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Mouse Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E03C2253-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E09C2253-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Monkey Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E09C2253-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Monkey Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E09C2253-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Monkey Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E02C2253-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E02C2253-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E02C2253-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Suppressor of cytokine signaling 1 inhibits the maturation of dendritic cells involving the nuclear issue kappa B signaling pathway within the glioma microenvironment
Recurrence and diffuse infiltration problem conventional therapeutic methods for malignant glioma. Immunotherapy seems to be a promising strategy to acquire long-term survival. Dendritic cells (DCs), essentially the most specialised and potent antigen-presenting cells (APCs), play an necessary half in initiating and amplifying each the innate and adaptive immune responses in opposition to most cancers cells. Nevertheless, most cancers cells can escape from immune surveillance by inhibiting maturation of DCs.
Till the current, molecular mechanisms of maturation inhibition of DCs within the tumor microenvironment (TME) haven’t been absolutely revealed. Our examine confirmed that pretreatment with tumor-conditioned medium (TCM) collected from supernatant of main glioma cells considerably suppressed the maturation of DCs.
TCM pretreatment considerably modified the morphology of DCs, TCM decreased the expression ranges of CD80, CD83, CD86 and interleukin (IL)-12p70, whereas it elevated the expression ranges of IL-10, reworking development issue (TGF)-β and IL-6. RNA-Seq confirmed that TCM pretreatment considerably elevated the gene expression stage of suppressor of cytokine signaling 1 (SOCS1) in DCs. suppressor of cytokine signaling 1 (SOCS1) knock-down considerably antagonized the maturation inhibition of DCs by TCM, which was demonstrated by the restoration of maturation markers.
Cytochrome P450 4A11 / 22 Blocking Peptide |
TCM pretreatment additionally considerably suppressed T cell viability and T helper sort 1 (Th1) response, and SOCS1 knock-down considerably antagonized this suppressive impact. Additional, TCM pretreatment considerably suppressed p65 nuclear translocation and transcriptional exercise in DCs, and SOCS1 knock-down considerably attenuated this suppressive impact.
In conclusion, our analysis demonstrates that TCM up-regulate SOCS1 to suppress the maturation of DCs by way of the nuclear factor-kappa signaling pathway.
Monoclonal CRLF2 Antibody (monoclonal) (M03), Clone: 4A11 |
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| AMM03416G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A Monoclonal antibody against Human CRLF2 (monoclonal) (M03). The antibodies are raised in mouse and are from clone 4A11. This antibody is applicable in WB, E |
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Monoclonal PARVB Antibody (monoclonal) (M01), Clone: 4A11 |
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| APR17756G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A Monoclonal antibody against Human PARVB (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4A11. This antibody is applicable in WB, E |
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anti-PDK1 (4A11) |
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| LF-MA30516 | Abfrontier | 100 ul | EUR 632.4 |
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Description: Mouse Monoclonal to PDK1 |
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anti-DLL4 (4A11) |
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| LF-MA30736 | Abfrontier | 100 ul | EUR 632.4 |
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Description: Mouse Monoclonal to DLL4 |
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anti-DLL4 (4A11) |
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| LF-MA30749 | Abfrontier | 100 ul | EUR 632.4 |
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Description: Mouse Monoclonal to DLL4 |
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TIGIT Antibody [4A11] |
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| RF16055-002mg | ProSci | 0.02 mg | EUR 229.7 |
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Description: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2). |
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TIGIT Antibody [4A11] |
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| RF16055-01mg | ProSci | 0.1 mg | EUR 594.26 |
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Description: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2). |
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Anti-APRIL (4A11) |
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| YF-MA16500 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to APRIL |
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Anti-SSX3 (4A11) |
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| YF-MA17194 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to SSX3 |
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Anti-MAP1 (4A11) |
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| YF-MA19202 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to MAP1 |
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Anti-CaMKK (4A11) |
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| YF-MA19533 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to CaMKK |
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Anti-LHX4 (4A11) |
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| YF-MA19614 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to LHX4 |
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Anti-CNKSR3 (4A11) |
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| YF-MA19966 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to CNKSR3 |
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Anti-FOXK2 (4A11) |
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| YF-MA20345 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to FOXK2 |
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Anti-JNK1 (4A11) |
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| YF-MA14911 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to JNK1 |
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Anti-PARVB (4A11) |
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| YF-MA11471 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to PARVB |
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Anti-THUMPD1 (4A11) |
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| YF-MA11563 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to THUMPD1 |
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Anti-CRLF2 (4A11) |
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| YF-MA11626 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to CRLF2 |
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Anti-ASFV P72 Antibody | MASF-5A-Clone #10E11 |
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| MASF-5A-Clone-10E11 | Immunology Consultants Laboratory | 1 mg | EUR 667 |
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Description: Anti-ASFV P72 Antibody | MASF-5A-Clone #10E11 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Anti-ASFV P72 Antibody | MASF-5A-Clone #10G5 |
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| MASF-5A-Clone-10G5 | Immunology Consultants Laboratory | 1 mg | EUR 667 |
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Description: Anti-ASFV P72 Antibody | MASF-5A-Clone #10G5 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#3B11 |
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| MALV-30A-Clone-3B11 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
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Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#3B11 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#5A4 |
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| MALV-30A-Clone-5A4 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
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Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#5A4 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6C2 |
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| MALV-30A-Clone-6C2 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
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Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6C2 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6D7 |
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| MALV-30A-Clone-6D7 | Immunology Consultants Laboratory | 1.0 mg | EUR 448 |
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Description: Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6D7 | Immunology Consultants Laboratory Host: Mouse Format: Unconjugated AP Product Type: Primary Antibody Antibody Clonality: Monoclonal |
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Cytochrome P450 4A11 antibody |
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| 70R-12729 | Fitzgerald | 100 ul | EUR 548.4 |
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Description: Affinity purified Rabbit polyclonal Cytochrome P450 4A11 antibody |
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Cytochrome P450 4A11 antibody |
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| 22646-100ul | SAB | 100ul | EUR 468 |
Anti-Hey L (4A11) |
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| YF-MA18109 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to Hey L |
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Anti-Claudin 4 (4A11) |
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| YF-MA12513 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to Claudin 4 |
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Cytochrome P450 4A11/22 antibody |
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| 70R-49642 | Fitzgerald | 100 ul | EUR 292.8 |
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Description: Purified Polyclonal Cytochrome P450 4A11/22 antibody |
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Cytochrome P450 4A11/22 Antibody |
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| 35260-100ul | SAB | 100ul | EUR 302.4 |
Cytochrome P450 4A11/22 Antibody |
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| 35260-50ul | SAB | 50ul | EUR 224.4 |
Cytochrome P450 4A11 (CYP4A11) Antibody |
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| 20-abx006298 | Abbexa |
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Cytochrome P450 4A11 / 22 Antibody |
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| 20-abx009352 | Abbexa |
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Cytochrome P450 4A11 (CYP4A11) Antibody |
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| 20-abx111934 | Abbexa |
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Cytochrome P450 4A11 / 22 Antibody |
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| 20-abx015130 | Abbexa |
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Cytochrome P450 4A11 (CYP4A11) Antibody |
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| abx033743-400ul | Abbexa | 400 ul | EUR 627.6 |
Cytochrome P450 4A11 (CYP4A11) Antibody |
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| abx033743-80l | Abbexa | 80 µl | EUR 343.2 |
Cytochrome P450 4A11/22 Antibody |
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| ABD13062 | Lifescience Market | 100 ug | EUR 525.6 |
Cytochrome P450 4A11/22 Antibody |
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| ABD4749 | Lifescience Market | 100 ug | EUR 525.6 |
Cytochrome P450 4A11 (CYP4A11) Antibody |
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| 20-abx320269 | Abbexa |
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Cytochrome P450 4A11 (CYP4A11) Antibody |
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| 20-abx339223 | Abbexa |
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Cytochrome P450 4A11 (CYP4A11) Antibody |
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| abx232168-100ug | Abbexa | 100 ug | EUR 610.8 |
Cytochrome P450 4A11 (CYP4A11) Antibody |
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| 20-abx213072 | Abbexa |
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Cytochrome P450 4A11/22 Antibody |
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| DF4749 | Affbiotech | 200ul | EUR 420 |
Anti-Cyclin A1 (4A11-5B5) |
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| YF-MA16598 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to Cyclin A1 |
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Anti-Musashi 1 / Msi1 (4A11) |
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| YF-MA10581 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to Musashi 1 / Msi1 |
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Anti-NFkB p105 / p50 (4A11) |
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| YF-MA10626 | Abfrontier | 100 ug | EUR 435.6 |
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Description: Mouse monoclonal to NFkB p105 / p50 |
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Anti-Cytochrome P450 4A11/22 Antibody |
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| A03493 | BosterBio | 100ul | EUR 476.4 |
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Description: Rabbit Polyclonal Cytochrome P450 4A11/22 Antibody. Validated in WB and tested in Human. |
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Cytochrome P450 4A11 / 22 Blocking Peptide |
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| 20-abx062517 | Abbexa |
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Cytochrome P450 4A11/22 Blocking Peptide |
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| DF4749-BP | Affbiotech | 1mg | EUR 234 |
Cytochrome P450 4A11/22 Conjugated Antibody |
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| C35260 | SAB | 100ul | EUR 476.4 |
Human Cytochrome P450 4A11 (CYP4A11) ELISA Kit |
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| abx386773-96tests | Abbexa | 96 tests | EUR 1093.2 |
Goat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E06C2253-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Goat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E06C2253-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Goat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E06C2253-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Goat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E04C2253-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E04C2253-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E04C2253-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E03C2253-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E03C2253-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Mouse Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E03C2253-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E09C2253-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Monkey Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E09C2253-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Monkey Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E09C2253-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Monkey Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E02C2253-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E02C2253-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Cytochrome P450 4A11(CYP4A11) ELISA kit |
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| E02C2253-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rat Cytochrome P450 4A11(CYP4A11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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